Fund shareholders of Spyre Therapeutics Inc
ISIN US00773J2024 · United States · LEI 52990017AIJPRH3HQH40
- Fund shareholders
- 228
- Of which ETFs
- 41 187 other funds
- Value held
- 1.4B $ 33M SEK
- Share of capital
- 29.6 % of 88.2M shares on Jul 28, 2026
This issuer has other securities : Spyre Therapeutics, Inc. (US007CVR0207)
228 funds hold this company. This table lists the 227 that declare it in a regulatory filing. 1 more fund publishes its holdings in its own report. It is not in the table.
| Fund | Shares | Value | Weight in fund | Share of capital | |
|---|---|---|---|---|---|
| SMALLCAP World Fund Inc SMALLCAP World Fund Inc | 2,412,693 | 121.7M $ | 0.15 % | 2.74 % | as of Mar 31, 2026 ↗ |
| Fidelity Growth Company Fund Fidelity Mt. Vernon Street Trust | 2,268,205 | 97.6M $ | 0.12 % | 2.57 % | as of Feb 28, 2026 ↗ |
| VANGUARD TOTAL STOCK MARKET INDEX FUND VANGUARD INDEX FUNDS | 2,218,648 | 111.9M $ | 0.01 % | 2.52 % | as of Mar 31, 2026 ↗ |
| iShares Russell 2000 ETF iShares Trust | 1,685,561 | 85M $ | 0.12 % | 1.91 % | as of Mar 31, 2026 ↗ |
| State Street(R) SPDR(R) S&P(R) Biotech ETF SPDR SERIES TRUST | 1,069,556 | 53.9M $ | 0.73 % | 1.21 % | as of Mar 31, 2026 ↗ |
| Select Health Care Portfolio Fidelity Select Portfolios | 940,000 | 40.4M $ | 0.65 % | 1.07 % | as of Feb 28, 2026 ↗ |
| T. Rowe Price Health Sciences Fund, Inc. T. ROWE PRICE HEALTH SCIENCES FUND, INC. | 854,145 | 43.1M $ | 0.40 % | 0.97 % | as of Mar 31, 2026 ↗ |
| Fidelity Advisor Biotechnology Fund Fidelity Advisor Series VII | 851,772 | 63.4M $ | 3.33 % | 0.97 % | as of Apr 30, 2026 ↗ |
| Fidelity Small Cap Growth Fund Fidelity Securities Fund | 777,720 | 57.9M $ | 0.69 % | 0.88 % | as of Apr 30, 2026 ↗ |
| VANGUARD EXTENDED MARKET INDEX FUND VANGUARD INDEX FUNDS | 760,693 | 38.4M $ | 0.05 % | 0.86 % | as of Mar 31, 2026 ↗ |
| Fidelity Small Cap Index Fund Fidelity Salem Street Trust | 738,371 | 55M $ | 0.17 % | 0.84 % | as of Apr 30, 2026 ↗ |
| Fidelity Growth Company K6 Fund Fidelity Mt. Vernon Street Trust | 672,126 | 28.9M $ | 0.12 % | 0.76 % | as of Feb 28, 2026 ↗ |
| Fidelity Series Growth Company Fund Fidelity Mt. Vernon Street Trust | 591,812 | 25.5M $ | 0.12 % | 0.67 % | as of Feb 28, 2026 ↗ |
| iShares Biotechnology ETF iShares Trust | 478,909 | 24.2M $ | 0.30 % | 0.54 % | as of Mar 31, 2026 ↗ |
| Fidelity Advisor Health Care Fund Fidelity Advisor Series VII | 410,000 | 30.5M $ | 1.06 % | 0.46 % | as of Apr 30, 2026 ↗ |
| Select Biotechnology Portfolio Fidelity Select Portfolios | 401,953 | 17.3M $ | 0.32 % | 0.46 % | as of Feb 28, 2026 ↗ |
| Fidelity Stock Selector Small Cap Fund Fidelity Capital Trust | 383,335 | 28.5M $ | 0.41 % | 0.43 % | as of Apr 30, 2026 ↗ |
| Fidelity Small Cap Growth K6 Fund Fidelity Securities Fund | 383,326 | 28.5M $ | 0.67 % | 0.43 % | as of Apr 30, 2026 ↗ |
| iShares Russell 2000 Growth ETF iShares Trust | 377,778 | 19.1M $ | 0.16 % | 0.43 % | as of Mar 31, 2026 ↗ |
| Fidelity Extended Market Index Fund Fidelity Concord Street Trust | 356,393 | 15.3M $ | 0.04 % | 0.40 % | as of Feb 28, 2026 ↗ |
| VANGUARD RUSSELL 2000 INDEX FUND VANGUARD SCOTTSDALE FUNDS | 341,319 | 14.7M $ | 0.10 % | 0.39 % | as of Feb 28, 2026 ↗ |
| Schwab U.S. Small-Cap ETF SCHWAB STRATEGIC TRUST | 332,267 | 14.3M $ | 0.07 % | 0.38 % | as of Feb 28, 2026 ↗ |
| JPMorgan Small Cap Growth Fund JPMorgan Trust II | 331,592 | 16.7M $ | 0.77 % | 0.38 % | as of Mar 31, 2026 ↗ |
| Franklin Biotechnology Discovery Fund Franklin Strategic Series | 323,584 | 24.1M $ | 2.33 % | 0.37 % | as of Apr 30, 2026 ↗ |
| Fidelity Series Small Cap Opportunities Fund Fidelity Securities Fund | 293,347 | 21.8M $ | 0.43 % | 0.33 % | as of Apr 30, 2026 ↗ |
| Driehaus Small Cap Growth Fund Driehaus Mutual Funds | 278,936 | 14.1M $ | 1.23 % | 0.32 % | as of Mar 31, 2026 ↗ |
| T. Rowe Price Integrated U.S. Small-Cap Growth Equity Fund T. ROWE PRICE INTEGRATED EQUITY FUNDS, INC. | 273,547 | 13.8M $ | 0.17 % | 0.31 % | as of Mar 31, 2026 ↗ |
| Fidelity Small Cap Value Fund Fidelity Securities Fund | 246,764 | 18.4M $ | 0.36 % | 0.28 % | as of Apr 30, 2026 ↗ |
| iShares Russell 2000 Value ETF iShares Trust | 194,976 | 9.8M $ | 0.08 % | 0.22 % | as of Mar 31, 2026 ↗ |
| VIP Health Care Portfolio Variable Insurance Products Fund IV | 168,000 | 8.5M $ | 0.84 % | 0.19 % | as of Mar 31, 2026 ↗ |
| Schwab Small-Cap Index Fund SCHWAB CAPITAL TRUST | 163,777 | 12.2M $ | 0.17 % | 0.19 % | as of Apr 30, 2026 ↗ |
| SmallCap Growth Fund I Principal Funds, Inc | 158,331 | 11.8M $ | 0.50 % | 0.18 % | as of Apr 30, 2026 ↗ |
| Franklin Small Cap Growth Fund Franklin Strategic Series | 155,799 | 11.6M $ | 0.47 % | 0.18 % | as of Apr 30, 2026 ↗ |
| Emerald Growth Fund FINANCIAL INVESTORS TRUST | 153,485 | 11.4M $ | 0.81 % | 0.17 % | as of Apr 30, 2026 ↗ |
| VANGUARD HEALTH CARE INDEX FUND VANGUARD WORLD FUND | 147,345 | 6.3M $ | 0.03 % | 0.17 % | as of Feb 28, 2026 ↗ |
| Driehaus Micro Cap Growth Fund Driehaus Mutual Funds | 135,823 | 6.9M $ | 1.50 % | 0.15 % | as of Mar 31, 2026 ↗ |
| Fidelity Total Market Index Fund Fidelity Concord Street Trust | 127,761 | 5.5M $ | 0.00 % | 0.14 % | as of Feb 28, 2026 ↗ |
| Master Small Cap Index Series Quantitative Master Series LLC | 113,384 | 5.7M $ | 0.12 % | 0.13 % | as of Mar 31, 2026 ↗ |
| JPMorgan Small Cap Blend Fund JPMorgan Trust I | 107,050 | 5.4M $ | 0.38 % | 0.12 % | as of Mar 31, 2026 ↗ |
| Fidelity Series Total Market Index Fund Fidelity Concord Street Trust | 101,180 | 4.4M $ | 0.00 % | 0.11 % | as of Feb 28, 2026 ↗ |
| F/m Emerald Life Sciences Innovation ETF RBB Fund, Inc. | 97,976 | 4.2M $ | 4.41 % | 0.11 % | as of Feb 28, 2026 ↗ |
| iShares Core S&P Total U.S. Stock Market ETF iShares Trust | 92,090 | 4.6M $ | 0.01 % | 0.10 % | as of Mar 31, 2026 ↗ |
| Victory RS Small Cap Growth Fund Victory Portfolios | 89,818 | 4.5M $ | 1.36 % | 0.10 % | as of Mar 31, 2026 ↗ |
| Nuveen Small Cap Blend Index Fund TIAA-CREF Funds | 88,896 | 6.6M $ | 0.17 % | 0.10 % | as of Apr 30, 2026 ↗ |
| Column Small Cap Select Fund Trust for Professional Managers | 82,062 | 3.5M $ | 0.20 % | 0.09 % | as of Feb 28, 2026 ↗ |
| AST Small-Cap Equity Portfolio Advanced Series Trust | 78,174 | 3.9M $ | 0.21 % | 0.09 % | as of Mar 31, 2026 ↗ |
| Victory Science & Technology Fund Victory Portfolios III | 76,720 | 5.7M $ | 0.41 % | 0.09 % | as of Apr 30, 2026 ↗ |
| Small Cap Growth Stock Portfolio NORTHWESTERN MUTUAL SERIES FUND INC | 74,126 | 3.7M $ | 0.51 % | 0.08 % | as of Mar 31, 2026 ↗ |
| EQ/2000 Managed Volatility Portfolio EQ Advisors Trust | 72,045 | 3.6M $ | 0.11 % | 0.08 % | as of Mar 31, 2026 ↗ |
| ALPS Medical Breakthroughs ETF ALPS ETF TRUST | 69,157 | 3M $ | 2.15 % | 0.08 % | as of Feb 28, 2026 ↗ |
| JNL Multi-Manager Small Cap Growth Fund JNL Series Trust | 67,170 | 3.4M $ | 0.17 % | 0.08 % | as of Mar 31, 2026 ↗ |
| Adara Smaller Companies Fund RBB Fund, Inc. | 65,274 | 2.8M $ | 0.37 % | 0.07 % | as of Feb 28, 2026 ↗ |
| Direxion Daily S&P Biotech Bull 3X Shares Direxion Shares ETF Trust | 61,270 | 4.6M $ | 0.88 % | 0.07 % | as of Apr 30, 2026 ↗ |
| Nuveen Equity Index Fund TIAA-CREF Funds | 60,818 | 4.5M $ | 0.01 % | 0.07 % | as of Apr 30, 2026 ↗ |
| Fidelity Small Cap Stock Fund Fidelity Concord Street Trust | 58,410 | 4.3M $ | 0.34 % | 0.07 % | as of Apr 30, 2026 ↗ |
| THE HARTFORD SMALL COMPANY FUND HARTFORD MUTUAL FUNDS, INC | 53,728 | 4M $ | 0.60 % | 0.06 % | as of Apr 30, 2026 ↗ |
| HARTFORD SMALL CAP GROWTH HLS FUND HARTFORD SERIES FUND INC | 53,502 | 2.7M $ | 0.51 % | 0.06 % | as of Mar 31, 2026 ↗ |
| T. Rowe Price Health Sciences Portfolio T. ROWE PRICE EQUITY SERIES, INC. | 52,747 | 2.7M $ | 0.40 % | 0.06 % | as of Mar 31, 2026 ↗ |
| Multi-Manager Small Cap Equity Strategies Fund COLUMBIA FUNDS SERIES TRUST I | 49,243 | 2.1M $ | 0.17 % | 0.06 % | as of Feb 28, 2026 ↗ |
| HealthInvest Sustainable Healthcare Atle Fund Management AB | 47,480 | 22.7M SEK | 0.71 % | 0.05 % | as of Mar 31, 2026 ↗ |
| Fidelity Nasdaq Composite Index Fund Fidelity Concord Street Trust | 46,253 | 2M $ | 0.01 % | 0.05 % | as of Feb 28, 2026 ↗ |
| U.S. MICRO CAP PORTFOLIO DFA INVESTMENT DIMENSIONS GROUP INC | 46,121 | 3.4M $ | 0.05 % | 0.05 % | as of Apr 30, 2026 ↗ |
| LVIP SSGA Small-Cap Index Fund LINCOLN VARIABLE INSURANCE PRODUCTS TRUST | 45,400 | 2.3M $ | 0.12 % | 0.05 % | as of Mar 31, 2026 ↗ |
| Schwab Total Stock Market Index Fund SCHWAB CAPITAL TRUST | 44,003 | 3.3M $ | 0.01 % | 0.05 % | as of Apr 30, 2026 ↗ |
| VANGUARD RUSSELL 2000 GROWTH INDEX FUND VANGUARD SCOTTSDALE FUNDS | 42,335 | 1.8M $ | 0.13 % | 0.05 % | as of Feb 28, 2026 ↗ |
| Invesco Dorsey Wright SmallCap Momentum ETF Invesco Exchange-Traded Fund Trust II | 41,549 | 1.8M $ | 0.46 % | 0.05 % | as of Feb 28, 2026 ↗ |
| SMALL CAP EQUITY FUND GuideStone Funds | 40,826 | 2.1M $ | 0.25 % | 0.05 % | as of Mar 31, 2026 ↗ |
| VANGUARD BALANCED INDEX FUND VANGUARD VALLEY FORGE FUNDS | 39,646 | 2M $ | 0.00 % | 0.04 % | as of Mar 31, 2026 ↗ |
| Schwab U.S. Broad Market ETF SCHWAB STRATEGIC TRUST | 38,369 | 1.7M $ | 0.00 % | 0.04 % | as of Feb 28, 2026 ↗ |
| EQ/Small Company Index Portfolio EQ Advisors Trust | 37,560 | 1.9M $ | 0.12 % | 0.04 % | as of Mar 31, 2026 ↗ |
| MassMutual Small Cap Growth Equity Fund MASSMUTUAL SELECT FUNDS | 37,517 | 1.9M $ | 0.34 % | 0.04 % | as of Mar 31, 2026 ↗ |
| T.Rowe Price Small Cap Growth Portfolio Brighthouse Funds Trust II | 36,165 | 1.8M $ | 0.17 % | 0.04 % | as of Mar 31, 2026 ↗ |
| Fidelity ZERO Total Market Index Fund Fidelity Concord Street Trust | 35,451 | 2.6M $ | 0.01 % | 0.04 % | as of Apr 30, 2026 ↗ |
| Fidelity Small Cap Growth Index Fund Fidelity Salem Street Trust | 35,123 | 1.8M $ | 0.16 % | 0.04 % | as of Mar 31, 2026 ↗ |
| HARTFORD SMALL COMPANY HLS FUND HARTFORD SERIES FUND INC | 34,711 | 1.8M $ | 0.45 % | 0.04 % | as of Mar 31, 2026 ↗ |
| VANGUARD INSTITUTIONAL TOTAL STOCK MARKET INDEX FUND VANGUARD INSTITUTIONAL INDEX FUNDS | 34,495 | 1.7M $ | 0.01 % | 0.04 % | as of Mar 31, 2026 ↗ |
| iShares U.S. Small-Cap Equity Factor ETF iShares Trust | 33,970 | 2.5M $ | 0.07 % | 0.04 % | as of Apr 30, 2026 ↗ |
| JPMorgan U.S. Small Company Fund JPMorgan Trust I | 33,081 | 1.7M $ | 0.18 % | 0.04 % | as of Mar 31, 2026 ↗ |
| Global X Russell 2000 ETF GLOBAL X FUNDS | 32,342 | 2.4M $ | 0.17 % | 0.04 % | as of Apr 30, 2026 ↗ |
| Small Cap Index Fund Northern Funds | 32,216 | 1.6M $ | 0.12 % | 0.04 % | as of Mar 31, 2026 ↗ |
| JPMorgan Small Cap Value Fund JPMorgan Trust II | 30,359 | 1.5M $ | 0.13 % | 0.03 % | as of Mar 31, 2026 ↗ |
| Invesco RAFI US 1500 Small-Mid ETF Invesco Exchange-Traded Fund Trust | 28,492 | 2.1M $ | 0.07 % | 0.03 % | as of Apr 30, 2026 ↗ |
| Fidelity Small Cap Value Index Fund Fidelity Salem Street Trust | 28,102 | 1.4M $ | 0.08 % | 0.03 % | as of Mar 31, 2026 ↗ |
| Small Cap Index Fund VALIC Co I | 27,796 | 1.2M $ | 0.10 % | 0.03 % | as of Feb 28, 2026 ↗ |
| Fidelity Nasdaq Composite Index ETF Fidelity Commonwealth Trust | 26,269 | 1.1M $ | 0.01 % | 0.03 % | as of Feb 28, 2026 ↗ |
| The Hartford Small Cap Growth Fund HARTFORD MUTUAL FUNDS II, INC | 26,081 | 1.9M $ | 0.64 % | 0.03 % | as of Apr 30, 2026 ↗ |
| Destinations Small-Mid Cap Equity Fund Brinker Capital Destinations Trust | 25,687 | 1.1M $ | 0.15 % | 0.03 % | as of Feb 28, 2026 ↗ |
| JPMorgan BetaBuilders U.S. Small Cap Equity ETF J.P. Morgan Exchange-Traded Fund Trust | 24,522 | 1.8M $ | 0.25 % | 0.03 % | as of Apr 30, 2026 ↗ |
| STATE STREET SMALL/MID CAP EQUITY INDEX PORTFOLIO STATE STREET INSTITUTIONAL INVESTMENT TRUST | 24,300 | 1.2M $ | 0.05 % | 0.03 % | as of Mar 31, 2026 ↗ |
| Invesco Dorsey Wright Healthcare Momentum ETF Invesco Exchange-Traded Fund Trust | 24,120 | 1.8M $ | 1.49 % | 0.03 % | as of Apr 30, 2026 ↗ |
| Fidelity ZERO Extended Market Index Fund Fidelity Concord Street Trust | 23,998 | 1.8M $ | 0.07 % | 0.03 % | as of Apr 30, 2026 ↗ |
| EQ/AB Small Cap Growth Portfolio EQ Advisors Trust | 23,870 | 1.2M $ | 0.06 % | 0.03 % | as of Mar 31, 2026 ↗ |
| Fidelity MSCI Health Care Index ETF FIDELITY COVINGTON TRUST | 22,417 | 1.7M $ | 0.06 % | 0.03 % | as of Apr 30, 2026 ↗ |
| MetLife Russell 2000 Index Portfolio Brighthouse Funds Trust II | 22,411 | 1.1M $ | 0.12 % | 0.03 % | as of Mar 31, 2026 ↗ |
| Small Cap Stock Trust John Hancock Variable Insurance Trust | 22,308 | 1.1M $ | 0.45 % | 0.03 % | as of Mar 31, 2026 ↗ |
| Strategic Advisers U.S. Total Stock Fund Fidelity Rutland Square Trust II | 22,221 | 955.7K $ | 0.00 % | 0.03 % | as of Feb 28, 2026 ↗ |
| HealthInvest Small & Mid Cap Healthcare Atle Fund Management AB | 21,628 | 10.3M SEK | 1.04 % | 0.02 % | as of Mar 31, 2026 ↗ |
| Transamerica T. Rowe Price Small Cap VP TRANSAMERICA SERIES TRUST | 21,619 | 1.1M $ | 0.17 % | 0.02 % | as of Mar 31, 2026 ↗ |
| ATM Small Cap Managed Volatility Portfolio EQ Advisors Trust | 20,493 | 1M $ | 0.11 % | 0.02 % | as of Mar 31, 2026 ↗ |
| Victory RS Science & Technology Fund Victory Portfolios | 19,808 | 999.1K $ | 0.53 % | 0.02 % | as of Mar 31, 2026 ↗ |
The funds most exposed to it
The weight is the share of a fund's net assets. The holders table ranks funds by number of shares. This one ranks them by the weight of the company in each fund.
| Fund | Weight in fund | |
|---|---|---|
| F/m Emerald Life Sciences Innovation ETF RBB Fund, Inc. | 4.41 % | as of Feb 28, 2026 ↗ |
| Fidelity Advisor Biotechnology Fund Fidelity Advisor Series VII | 3.33 % | as of Apr 30, 2026 ↗ |
| Franklin Biotechnology Discovery Fund Franklin Strategic Series | 2.33 % | as of Apr 30, 2026 ↗ |
| ALGER HEALTH SCIENCES FUND ALGER FUNDS | 2.32 % | as of Apr 30, 2026 ↗ |
| ALPS Medical Breakthroughs ETF ALPS ETF TRUST | 2.15 % | as of Feb 28, 2026 ↗ |
| Virtus Biotech Clinical Trials Etf ETFis Series Trust I | 1.64 % | as of Apr 30, 2026 ↗ |
| Driehaus Micro Cap Growth Fund Driehaus Mutual Funds | 1.50 % | as of Mar 31, 2026 ↗ |
| Invesco Dorsey Wright Healthcare Momentum ETF Invesco Exchange-Traded Fund Trust | 1.49 % | as of Apr 30, 2026 ↗ |
| Victory RS Small Cap Growth Fund Victory Portfolios | 1.36 % | as of Mar 31, 2026 ↗ |
| Driehaus Small Cap Growth Fund Driehaus Mutual Funds | 1.23 % | as of Mar 31, 2026 ↗ |
Quarter after quarter
Each row is one quarter of SEC filings, newest first. The change compares each quarter with the one before.
| Quarter | Shareholders | Change | Shares | Change |
|---|---|---|---|---|
| 2026Q2 | 225 | +40 | 26,042,960 | +1.1 % |
| 2026Q1 | 185 | +11 | 25,756,005 | +29.0 % |
| 2025Q4 | 174 | +1 | 19,973,050 | +2.6 % |
| 2025Q3 | 173 | +6 | 19,461,233 | +3.1 % |
| 2025Q2 | 167 | +7 | 18,867,348 | +13.8 % |
| 2025Q1 | 160 | +12 | 16,573,727 | +30.6 % |
| 2024Q4 | 148 | +61 | 12,691,514 | +30.7 % |
| 2024Q3 | 87 | +44 | 9,708,791 | +87.7 % |
| 2024Q2 | 43 | +24 | 5,173,281 | +257.3 % |
| 2024Q1 | 19 | +15 | 1,447,899 | +3,730.1 % |
| 2023Q4 | 4 | 37,803 |
Institutional managers
189 managers declare this company to the SEC (Form 13F). The table shows the 25 largest.
| Manager | Shares | Value | |
|---|---|---|---|
| FMR LLC | 11,781,024 | 594.2M $ | as of Mar 31, 2026 |
| BlackRock, Inc. | 5,521,221 | 278.5M $ | as of Mar 31, 2026 |
| RTW INVESTMENTS, LP | 4,171,996 | 210.4M $ | as of Mar 31, 2026 |
| Fairmount Funds Management LLC | 4,018,101 | 202.7M $ | as of Mar 31, 2026 |
| PERCEPTIVE ADVISORS LLC | 3,783,225 | 190.8M $ | as of Mar 31, 2026 |
| Venrock Adviser, LLC | 3,685,448 | 185.9M $ | as of Mar 31, 2026 |
| Driehaus Capital Management LLC | 2,790,785 | 140.8M $ | as of Mar 31, 2026 |
| STATE STREET CORP | 2,607,031 | 131.5M $ | as of Mar 31, 2026 |
| Paradigm Biocapital Advisors LP | 1,957,266 | 98.7M $ | as of Mar 31, 2026 |
| Commodore Capital LP | 1,912,380 | 96.5M $ | as of Mar 31, 2026 |
| TCG Crossover Management, LLC | 1,900,582 | 95.9M $ | as of Mar 31, 2026 |
| TANG CAPITAL MANAGEMENT LLC | 1,892,200 | 95.4M $ | as of Mar 31, 2026 |
| WELLINGTON MANAGEMENT GROUP LLP | 1,824,811 | 92M $ | as of Mar 31, 2026 |
| Capital International Investors | 1,746,129 | 88.1M $ | as of Mar 31, 2026 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,720,912 | 86.8M $ | as of Mar 31, 2026 |
| JANUS HENDERSON GROUP PLC | 1,656,164 | 83.6M $ | as of Mar 31, 2026 |
| RA CAPITAL MANAGEMENT, L.P. | 1,621,620 | 81.8M $ | as of Mar 31, 2026 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,598,730 | 80.6K $ | as of Mar 31, 2026 |
| Remedium Capital Partners, LLC | 1,456,231 | 73.5M $ | as of Mar 31, 2026 |
| Affinity Asset Advisors, LLC | 1,279,134 | 64.5M $ | as of Mar 31, 2026 |
| BANK OF AMERICA CORP /DE/ | 1,228,093 | 61.9M $ | as of Mar 31, 2026 |
| BAKER BROS. ADVISORS LP | 1,000,000 | 50.4M $ | as of Mar 31, 2026 |
| JPMORGAN CHASE & CO | 979,299 | 44.5M $ | as of Mar 31, 2026 |
| BRAIDWELL LP | 932,823 | 47.1M $ | as of Mar 31, 2026 |
| FRANKLIN RESOURCES INC | 882,833 | 44.5M $ | as of Mar 31, 2026 |
Declared shareholders of Spyre Therapeutics Inc
There are 2 beneficial ownership filings. These stakes do not add up. An asset manager that files includes its own funds, which already appear among the funds on this page.
| Shareholder | Declared stake | Shares | |
|---|---|---|---|
| Fairmount Funds Management LLC and 3 others | 9.99 % | 9,667,201 | as of Jun 23, 2026 · SCHEDULE 13D |
| Perceptive Advisors LLC and 2 others | 5.00 % | 4,319,496 | as of Apr 15, 2026 · SCHEDULE 13G |
Cite this page
Titelia. "Fund shareholders of Spyre Therapeutics Inc". https://titelia.com/en/stocks/spyre-therapeutics-inc-US00773J2024