Fund shareholders of Spyre Therapeutics Inc
ISIN US00773J2024 · United States · LEI 52990017AIJPRH3HQH40
- Fund shareholders
- 301
- Of which ETFs
- 57 244 other funds
- Value held
- ≈ 3B $ 2.9B $ · 33M SEK
- Share of capital
- 38.4 % of 88.2M shares on Jul 28, 2026
This issuer has other securities: Spyre Therapeutics, Inc. (US007CVR0207)
301 funds hold this company. This table lists the 300 that declare it in a regulatory filing. 1 more fund publishes its holdings in its own report. The “Fund reports” tab lists it, with its weight.
| Fund | Shares | Value | Weight in fund | Share of capital | |
|---|---|---|---|---|---|
| SMALLCAP World Fund Inc SMALLCAP World Fund Inc | 2,780,536 | 246.9M $ | 0.26 % | 3.15 % | as of Jun 30, 2026 ↗ |
| Fidelity Growth Company Fund Fidelity Mt. Vernon Street Trust | 2,576,969 | 189.4M $ | 0.19 % | 2.92 % | as of May 31, 2026 ↗ |
| VANGUARD TOTAL STOCK MARKET INDEX FUND VANGUARD INDEX FUNDS | 2,482,298 | 220.4M $ | 0.01 % | 2.82 % | as of Jun 30, 2026 ↗ |
| iShares Russell 2000 ETF iShares Trust | 1,911,678 | 169.7M $ | 0.20 % | 2.17 % | as of Jun 30, 2026 ↗ |
| State Street(R) SPDR(R) S&P(R) Biotech ETF SPDR SERIES TRUST | 1,326,035 | 117.7M $ | 1.10 % | 1.50 % | as of Jun 30, 2026 ↗ |
| VANGUARD SMALL-CAP INDEX FUND VANGUARD INDEX FUNDS | 896,559 | 79.6M $ | 0.04 % | 1.02 % | as of Jun 30, 2026 ↗ |
| VANGUARD EXTENDED MARKET INDEX FUND VANGUARD INDEX FUNDS | 886,177 | 78.7M $ | 0.08 % | 1.01 % | as of Jun 30, 2026 ↗ |
| Fidelity Advisor Biotechnology Fund Fidelity Advisor Series VII | 857,347 | 84.3M $ | 3.83 % | 0.97 % | as of Jul 31, 2026 ↗ |
| Fidelity Small Cap Index Fund Fidelity Salem Street Trust | 814,290 | 80.1M $ | 0.24 % | 0.92 % | as of Jul 31, 2026 ↗ |
| Fidelity Small Cap Growth Fund Fidelity Securities Fund | 777,720 | 76.5M $ | 0.87 % | 0.88 % | as of Jul 31, 2026 ↗ |
| Select Health Care Portfolio Fidelity Select Portfolios | 760,000 | 55.9M $ | 0.97 % | 0.86 % | as of May 31, 2026 ↗ |
| Fidelity Growth Company K6 Fund Fidelity Mt. Vernon Street Trust | 749,630 | 55.1M $ | 0.20 % | 0.85 % | as of May 31, 2026 ↗ |
| T. Rowe Price Health Sciences Fund, Inc. T. ROWE PRICE HEALTH SCIENCES FUND, INC. | 711,845 | 63.2M $ | 0.53 % | 0.81 % | as of Jun 30, 2026 ↗ |
| iShares Russell 2000 Growth ETF iShares Trust | 687,511 | 61M $ | 0.40 % | 0.78 % | as of Jun 30, 2026 ↗ |
| T. Rowe Price New Horizons Fund, Inc. T. ROWE PRICE NEW HORIZONS FUND, INC. | 673,799 | 59.8M $ | 0.41 % | 0.76 % | as of Jun 30, 2026 ↗ |
| Fidelity Series Growth Company Fund Fidelity Mt. Vernon Street Trust | 671,191 | 49.3M $ | 0.20 % | 0.76 % | as of May 31, 2026 ↗ |
| VANGUARD SMALL-CAP VALUE INDEX FUND VANGUARD INDEX FUNDS | 567,724 | 50.4M $ | 0.07 % | 0.64 % | as of Jun 30, 2026 ↗ |
| iShares Biotechnology ETF iShares Trust | 547,684 | 48.6M $ | 0.54 % | 0.62 % | as of Jun 30, 2026 ↗ |
| T. Rowe Price Integrated U.S. Small-Cap Growth Equity Fund T. ROWE PRICE INTEGRATED EQUITY FUNDS, INC. | 509,247 | 45.2M $ | 0.46 % | 0.58 % | as of Jun 30, 2026 ↗ |
| VANGUARD EXPLORER FUND VANGUARD EXPLORER FUND | 489,165 | 48.1M $ | 0.22 % | 0.55 % | as of Jul 31, 2026 ↗ |
| Select Biotechnology Portfolio Fidelity Select Portfolios | 403,153 | 29.6M $ | 0.56 % | 0.46 % | as of May 31, 2026 ↗ |
| Fidelity Extended Market Index Fund Fidelity Concord Street Trust | 384,291 | 28.2M $ | 0.07 % | 0.44 % | as of May 31, 2026 ↗ |
| VANGUARD RUSSELL 2000 INDEX FUND VANGUARD SCOTTSDALE FUNDS | 383,517 | 28.2M $ | 0.16 % | 0.43 % | as of May 31, 2026 ↗ |
| Fidelity Stock Selector Small Cap Fund Fidelity Capital Trust | 383,335 | 37.7M $ | 0.51 % | 0.43 % | as of Jul 31, 2026 ↗ |
| Fidelity Small Cap Growth K6 Fund Fidelity Securities Fund | 383,326 | 37.7M $ | 0.82 % | 0.43 % | as of Jul 31, 2026 ↗ |
| Schwab U.S. Small-Cap ETF SCHWAB STRATEGIC TRUST | 360,437 | 26.5M $ | 0.12 % | 0.41 % | as of May 31, 2026 ↗ |
| Fidelity Advisor Health Care Fund Fidelity Advisor Series VII | 340,000 | 33.4M $ | 1.07 % | 0.39 % | as of Jul 31, 2026 ↗ |
| Janus Henderson Global Life Sciences Fund Janus Investment Fund | 328,592 | 29.2M $ | 0.50 % | 0.37 % | as of Jun 30, 2026 ↗ |
| Driehaus Small Cap Growth Fund Driehaus Mutual Funds | 309,152 | 27.4M $ | 1.70 % | 0.35 % | as of Jun 30, 2026 ↗ |
| Fidelity Contrafund Fidelity Contrafund | 295,700 | 26.3M $ | 0.01 % | 0.34 % | as of Jun 30, 2026 ↗ |
| Fidelity Series Small Cap Opportunities Fund Fidelity Securities Fund | 293,347 | 28.8M $ | 0.61 % | 0.33 % | as of Jul 31, 2026 ↗ |
| Putnam Small Cap Growth Fund Putnam Funds Trust | 263,526 | 23.4M $ | 0.69 % | 0.30 % | as of Jun 30, 2026 ↗ |
| JPMorgan Small Cap Growth Fund JPMorgan Trust II | 261,269 | 23.2M $ | 0.89 % | 0.30 % | as of Jun 30, 2026 ↗ |
| Victory Pioneer Select Mid Cap Growth Fund Victory Portfolios IV | 249,308 | 18.3M $ | 0.97 % | 0.28 % | as of May 31, 2026 ↗ |
| Franklin Biotechnology Discovery Fund Franklin Strategic Series | 245,009 | 24.1M $ | 2.09 % | 0.28 % | as of Jul 31, 2026 ↗ |
| ClearBridge Small Cap Growth Fund Legg Mason Partners Investment Trust | 209,500 | 20.6M $ | 1.08 % | 0.24 % | as of Jul 31, 2026 ↗ |
| Fidelity SAI Small-Mid Cap Momentum Index Fund Fidelity Salem Street Trust | 208,605 | 20.5M $ | 0.49 % | 0.24 % | as of Jul 31, 2026 ↗ |
| Eventide Healthcare & Life Sciences Fund MUTUAL FUND SERIES TRUST | 200,000 | 17.8M $ | 0.99 % | 0.23 % | as of Jun 30, 2026 ↗ |
| Franklin Small Cap Growth Fund Franklin Strategic Series | 195,293 | 19.2M $ | 0.78 % | 0.22 % | as of Jul 31, 2026 ↗ |
| Schwab Small-Cap Index Fund SCHWAB CAPITAL TRUST | 180,878 | 17.8M $ | 0.24 % | 0.21 % | as of Jul 31, 2026 ↗ |
| SmallCap Growth Fund I Principal Funds, Inc | 161,595 | 15.9M $ | 0.64 % | 0.18 % | as of Jul 31, 2026 ↗ |
| Emerald Growth Fund RBB Fund, Inc. | 153,485 | 15.1M $ | 1.02 % | 0.17 % | as of Jul 31, 2026 ↗ |
| VANGUARD HEALTH CARE INDEX FUND VANGUARD WORLD FUND | 146,746 | 10.8M $ | 0.06 % | 0.17 % | as of May 31, 2026 ↗ |
| Fidelity Total Market Index Fund Fidelity Concord Street Trust | 141,090 | 10.4M $ | 0.01 % | 0.16 % | as of May 31, 2026 ↗ |
| Fidelity Small Cap Value Fund Fidelity Securities Fund | 137,664 | 13.5M $ | 0.25 % | 0.16 % | as of Jul 31, 2026 ↗ |
| Master Small Cap Index Series Quantitative Master Series LLC | 137,310 | 12.2M $ | 0.20 % | 0.16 % | as of Jun 30, 2026 ↗ |
| Driehaus Micro Cap Growth Fund Driehaus Mutual Funds | 134,180 | 11.9M $ | 2.00 % | 0.15 % | as of Jun 30, 2026 ↗ |
| VIP Health Care Portfolio Variable Insurance Products Fund IV | 128,000 | 11.4M $ | 0.98 % | 0.15 % | as of Jun 30, 2026 ↗ |
| Fidelity Series Total Market Index Fund Fidelity Concord Street Trust | 114,368 | 8.4M $ | 0.01 % | 0.13 % | as of May 31, 2026 ↗ |
| Calamos Timpani Small Cap Growth Fund CALAMOS INVESTMENT TRUST/IL | 104,841 | 10.3M $ | 1.35 % | 0.12 % | as of Jul 31, 2026 ↗ |
| iShares Core S&P Total U.S. Stock Market ETF iShares Trust | 102,323 | 9.1M $ | 0.01 % | 0.12 % | as of Jun 30, 2026 ↗ |
| Nuveen Small Cap Blend Index Fund TIAA-CREF Funds | 97,139 | 9.6M $ | 0.23 % | 0.11 % | as of Jul 31, 2026 ↗ |
| F/m Emerald Life Sciences Innovation ETF RBB Fund, Inc. | 91,588 | 6.7M $ | 6.41 % | 0.10 % | as of May 31, 2026 ↗ |
| Victory RS Small Cap Growth Fund Victory Portfolios | 85,798 | 7.6M $ | 1.87 % | 0.10 % | as of Jun 30, 2026 ↗ |
| JPMorgan Small Cap Blend Fund JPMorgan Trust I | 83,045 | 7.4M $ | 0.44 % | 0.09 % | as of Jun 30, 2026 ↗ |
| Column Small Cap Select Fund Trust for Professional Managers | 82,062 | 6M $ | 0.32 % | 0.09 % | as of May 31, 2026 ↗ |
| ALPS Medical Breakthroughs ETF ALPS ETF TRUST | 80,958 | 6M $ | 3.68 % | 0.09 % | as of May 31, 2026 ↗ |
| EQ/2000 Managed Volatility Portfolio EQ Advisors Trust | 80,844 | 7.2M $ | 0.19 % | 0.09 % | as of Jun 30, 2026 ↗ |
| Small Cap Growth Stock Portfolio NORTHWESTERN MUTUAL SERIES FUND INC | 77,732 | 6.9M $ | 0.76 % | 0.09 % | as of Jun 30, 2026 ↗ |
| Victory Science & Technology Fund Victory Portfolios III | 76,720 | 7.5M $ | 0.50 % | 0.09 % | as of Jul 31, 2026 ↗ |
| SMALLCAP World Fund AMERICAN FUNDS INSURANCE SERIES | 75,891 | 6.7M $ | 0.26 % | 0.09 % | as of Jun 30, 2026 ↗ |
| JNL Multi-Manager Small Cap Growth Fund JNL Series Trust | 75,669 | 6.7M $ | 0.26 % | 0.09 % | as of Jun 30, 2026 ↗ |
| AST Small-Cap Equity Portfolio Advanced Series Trust | 74,836 | 6.6M $ | 0.31 % | 0.08 % | as of Jun 30, 2026 ↗ |
| Fidelity Small Cap Growth Index Fund Fidelity Salem Street Trust | 69,788 | 6.2M $ | 0.40 % | 0.08 % | as of Jun 30, 2026 ↗ |
| Adara Smaller Companies Fund RBB Fund, Inc. | 65,274 | 4.8M $ | 0.58 % | 0.07 % | as of May 31, 2026 ↗ |
| Fidelity Momentum Factor ETF Fidelity Covington Trust | 64,674 | 6.4M $ | 0.70 % | 0.07 % | as of Jul 31, 2026 ↗ |
| PGIM Jennison Health Sciences Fund Prudential Sector Funds, Inc. | 64,063 | 4.7M $ | 0.34 % | 0.07 % | as of May 29, 2026 ↗ |
| Fidelity Contrafund K6 Fidelity Contrafund | 61,890 | 5.5M $ | 0.01 % | 0.07 % | as of Jun 30, 2026 ↗ |
| Nuveen Equity Index Fund TIAA-CREF Funds | 60,818 | 6M $ | 0.01 % | 0.07 % | as of Jul 31, 2026 ↗ |
| T.Rowe Price Small Cap Growth Portfolio Brighthouse Funds Trust II | 59,026 | 5.2M $ | 0.46 % | 0.07 % | as of Jun 30, 2026 ↗ |
| Fidelity Small Cap Stock Fund Fidelity Concord Street Trust | 58,410 | 5.7M $ | 0.43 % | 0.07 % | as of Jul 31, 2026 ↗ |
| HARTFORD SMALL CAP GROWTH HLS FUND HARTFORD SERIES FUND INC | 57,014 | 5.1M $ | 0.76 % | 0.06 % | as of Jun 30, 2026 ↗ |
| THE HARTFORD SMALL COMPANY FUND HARTFORD MUTUAL FUNDS, INC | 53,458 | 5.3M $ | 0.78 % | 0.06 % | as of Jul 31, 2026 ↗ |
| SMALL COMPANY GROWTH PORTFOLIO VANGUARD VARIABLE INSURANCE FUNDS | 51,896 | 4.6M $ | 0.27 % | 0.06 % | as of Jun 30, 2026 ↗ |
| LVIP State Street Small-Cap Index Fund LINCOLN VARIABLE INSURANCE PRODUCTS TRUST | 51,500 | 4.6M $ | 0.20 % | 0.06 % | as of Jun 30, 2026 ↗ |
| BlackRock Advantage Small Cap Core Fund BlackRock Funds | 50,182 | 3.7M $ | 0.07 % | 0.06 % | as of May 29, 2026 ↗ |
| Federated Hermes MDT Small Cap Growth Fund Federated Hermes MDT Series | 50,112 | 4.9M $ | 0.59 % | 0.06 % | as of Jul 31, 2026 ↗ |
| Invesco Dorsey Wright Healthcare Momentum ETF Invesco Exchange-Traded Fund Trust | 48,127 | 4.7M $ | 2.01 % | 0.05 % | as of Jul 31, 2026 ↗ |
| T. Rowe Price Health Sciences Portfolio T. ROWE PRICE EQUITY SERIES, INC. | 47,651 | 4.2M $ | 0.56 % | 0.05 % | as of Jun 30, 2026 ↗ |
| Multi-Manager Small Cap Equity Strategies Fund COLUMBIA FUNDS SERIES TRUST I | 47,561 | 3.5M $ | 0.27 % | 0.05 % | as of May 31, 2026 ↗ |
| HealthInvest Sustainable Healthcare Atle Fund Management AB | 47,480 | 22.7M SEK | 0.71 % | 0.05 % | as of Mar 31, 2026 ↗ |
| Fidelity Nasdaq Composite Index Fund Fidelity Concord Street Trust | 47,242 | 3.5M $ | 0.01 % | 0.05 % | as of May 31, 2026 ↗ |
| Fidelity Advisor Growth Opportunities Fund Fidelity Advisor Series I | 47,000 | 3.5M $ | 0.01 % | 0.05 % | as of May 31, 2026 ↗ |
| VANGUARD RUSSELL 2000 GROWTH INDEX FUND VANGUARD SCOTTSDALE FUNDS | 46,926 | 3.4M $ | 0.21 % | 0.05 % | as of May 31, 2026 ↗ |
| Schwab Total Stock Market Index Fund SCHWAB CAPITAL TRUST | 46,825 | 4.6M $ | 0.01 % | 0.05 % | as of Jul 31, 2026 ↗ |
| U.S. MICRO CAP PORTFOLIO DFA INVESTMENT DIMENSIONS GROUP INC | 46,121 | 4.5M $ | 0.06 % | 0.05 % | as of Jul 31, 2026 ↗ |
| Direxion Daily S&P Biotech Bull 3X Shares Direxion Shares ETF Trust | 44,942 | 4.4M $ | 0.89 % | 0.05 % | as of Jul 31, 2026 ↗ |
| EQ/Small Company Index Portfolio EQ Advisors Trust | 44,150 | 3.9M $ | 0.21 % | 0.05 % | as of Jun 30, 2026 ↗ |
| Schwab U.S. Broad Market ETF SCHWAB STRATEGIC TRUST | 44,082 | 3.2M $ | 0.01 % | 0.05 % | as of May 31, 2026 ↗ |
| Small-Cap Growth Portfolio PACIFIC SELECT FUND | 42,736 | 3.8M $ | 0.64 % | 0.05 % | as of Jun 30, 2026 ↗ |
| Fidelity ZERO Total Market Index Fund Fidelity Concord Street Trust | 41,946 | 4.1M $ | 0.01 % | 0.05 % | as of Jul 31, 2026 ↗ |
| VANGUARD BALANCED INDEX FUND VANGUARD VALLEY FORGE FUNDS | 41,738 | 3.7M $ | 0.01 % | 0.05 % | as of Jun 30, 2026 ↗ |
| VictoryShares US Small Mid Cap Value Momentum ETF Victory Portfolios II | 40,598 | 3.6M $ | 0.21 % | 0.05 % | as of Jun 30, 2026 ↗ |
| VANGUARD U.S. MOMENTUM FACTOR ETF VANGUARD WELLINGTON FUND | 39,684 | 2.9M $ | 0.16 % | 0.05 % | as of May 31, 2026 ↗ |
| VIP Contrafund Portfolio Variable Insurance Products Fund II | 38,500 | 3.4M $ | 0.01 % | 0.04 % | as of Jun 30, 2026 ↗ |
| Small Cap Index Fund Northern Funds | 37,656 | 3.3M $ | 0.20 % | 0.04 % | as of Jun 30, 2026 ↗ |
| VANGUARD INSTITUTIONAL TOTAL STOCK MARKET INDEX FUND VANGUARD INSTITUTIONAL INDEX FUNDS | 37,364 | 3.3M $ | 0.01 % | 0.04 % | as of Jun 30, 2026 ↗ |
| Transamerica T. Rowe Price Small Cap VP TRANSAMERICA SERIES TRUST | 37,306 | 3.3M $ | 0.46 % | 0.04 % | as of Jun 30, 2026 ↗ |
| iShares U.S. Small-Cap Equity Factor ETF iShares Trust | 36,661 | 3.6M $ | 0.09 % | 0.04 % | as of Jul 31, 2026 ↗ |
| Victory Small Cap Stock Fund Victory Portfolios III | 36,353 | 3.6M $ | 0.37 % | 0.04 % | as of Jul 31, 2026 ↗ |
Funds that publish their own holdings
| Fund | Weight in fund | |
|---|---|---|
| Pictet - Biotech Pictet Asset Management (Europe) S.A. | 0.64 % | as of Sep 30, 2025 ↗ |
The funds most exposed to it
The weight is the share of a fund's net assets. The holders table ranks funds by number of shares. This one ranks them by the weight of the company in each fund.
| Fund | Weight in fund | |
|---|---|---|
| F/m Emerald Life Sciences Innovation ETF RBB Fund, Inc. | 6.41 % | as of May 31, 2026 ↗ |
| Fidelity Advisor Biotechnology Fund Fidelity Advisor Series VII | 3.83 % | as of Jul 31, 2026 ↗ |
| ALPS Medical Breakthroughs ETF ALPS ETF TRUST | 3.68 % | as of May 31, 2026 ↗ |
| Franklin Biotechnology Discovery Fund Franklin Strategic Series | 2.09 % | as of Jul 31, 2026 ↗ |
| Invesco Dorsey Wright Healthcare Momentum ETF Invesco Exchange-Traded Fund Trust | 2.01 % | as of Jul 31, 2026 ↗ |
| Driehaus Micro Cap Growth Fund Driehaus Mutual Funds | 2.00 % | as of Jun 30, 2026 ↗ |
| Victory RS Small Cap Growth Fund Victory Portfolios | 1.87 % | as of Jun 30, 2026 ↗ |
| Driehaus Small Cap Growth Fund Driehaus Mutual Funds | 1.70 % | as of Jun 30, 2026 ↗ |
| Victory Pioneer Select Mid Cap Growth VCT Portfolio Victory Variable Insurance Funds II | 1.51 % | as of Jun 30, 2026 ↗ |
| Calamos Timpani Small Cap Growth Fund CALAMOS INVESTMENT TRUST/IL | 1.35 % | as of Jul 31, 2026 ↗ |
Quarter after quarter
Each row is one quarter of SEC filings, newest first. The change compares each quarter with the one before.
| Quarter | Shareholders | Change | Shares | Change |
|---|---|---|---|---|
| 2026Q3 | 298 | +73 | 33,796,755 | +29.8 % |
| 2026Q2 | 225 | +40 | 26,042,960 | +1.1 % |
| 2026Q1 | 185 | +11 | 25,756,005 | +29.0 % |
| 2025Q4 | 174 | +1 | 19,973,050 | +2.6 % |
| 2025Q3 | 173 | +6 | 19,461,233 | +3.1 % |
| 2025Q2 | 167 | +7 | 18,867,348 | +13.8 % |
| 2025Q1 | 160 | +12 | 16,573,727 | +30.6 % |
| 2024Q4 | 148 | +61 | 12,691,514 | +30.7 % |
| 2024Q3 | 87 | +44 | 9,708,791 | +87.7 % |
| 2024Q2 | 43 | +24 | 5,173,281 | +257.3 % |
| 2024Q1 | 19 | +15 | 1,447,899 | +3,730.1 % |
| 2023Q4 | 4 | 37,803 |
Institutional managers
189 managers declare this company to the SEC (Form 13F). The table shows the 25 largest.
| Manager | Shares | Value | |
|---|---|---|---|
| FMR LLC | 11,781,024 | 594.2M $ | as of Mar 31, 2026 |
| BlackRock, Inc. | 5,521,221 | 278.5M $ | as of Mar 31, 2026 |
| RTW INVESTMENTS, LP | 4,171,996 | 210.4M $ | as of Mar 31, 2026 |
| Fairmount Funds Management LLC | 4,018,101 | 202.7M $ | as of Mar 31, 2026 |
| PERCEPTIVE ADVISORS LLC | 3,783,225 | 190.8M $ | as of Mar 31, 2026 |
| Venrock Adviser, LLC | 3,685,448 | 185.9M $ | as of Mar 31, 2026 |
| Driehaus Capital Management LLC | 2,790,785 | 140.8M $ | as of Mar 31, 2026 |
| STATE STREET CORP | 2,607,031 | 131.5M $ | as of Mar 31, 2026 |
| Paradigm Biocapital Advisors LP | 1,957,266 | 98.7M $ | as of Mar 31, 2026 |
| Commodore Capital LP | 1,912,380 | 96.5M $ | as of Mar 31, 2026 |
| TCG Crossover Management, LLC | 1,900,582 | 95.9M $ | as of Mar 31, 2026 |
| TANG CAPITAL MANAGEMENT LLC | 1,892,200 | 95.4M $ | as of Mar 31, 2026 |
| WELLINGTON MANAGEMENT GROUP LLP | 1,824,811 | 92M $ | as of Mar 31, 2026 |
| Capital International Investors | 1,746,129 | 88.1M $ | as of Mar 31, 2026 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,720,912 | 86.8M $ | as of Mar 31, 2026 |
| JANUS HENDERSON GROUP PLC | 1,656,164 | 83.6M $ | as of Mar 31, 2026 |
| RA CAPITAL MANAGEMENT, L.P. | 1,621,620 | 81.8M $ | as of Mar 31, 2026 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,598,730 | 80.6K $ | as of Mar 31, 2026 |
| Remedium Capital Partners, LLC | 1,456,231 | 73.5M $ | as of Mar 31, 2026 |
| Affinity Asset Advisors, LLC | 1,279,134 | 64.5M $ | as of Mar 31, 2026 |
| BANK OF AMERICA CORP /DE/ | 1,228,093 | 61.9M $ | as of Mar 31, 2026 |
| BAKER BROS. ADVISORS LP | 1,000,000 | 50.4M $ | as of Mar 31, 2026 |
| JPMORGAN CHASE & CO | 979,299 | 44.5M $ | as of Mar 31, 2026 |
| BRAIDWELL LP | 932,823 | 47.1M $ | as of Mar 31, 2026 |
| FRANKLIN RESOURCES INC | 882,833 | 44.5M $ | as of Mar 31, 2026 |
Declared shareholders of Spyre Therapeutics Inc
There are 2 beneficial ownership filings. These stakes do not add up. An asset manager that files includes its own funds, which already appear among the funds on this page.
| Shareholder | Declared stake | Shares | |
|---|---|---|---|
| Perceptive Advisors LLC and 2 others | 4.90 % | 4,319,496 | as of Jun 30, 2026 · SCHEDULE 13G |
| RTW Investments, LP and 1 other | 4.80 % | 4,251,996 | as of Jun 30, 2026 · SCHEDULE 13G |
Cite this page
Titelia. "Fund shareholders of Spyre Therapeutics Inc". https://titelia.com/en/stocks/spyre-therapeutics-inc-US00773J2024