| 1 | Ascendis Pharma A/S | 10,281,496 | 2.4B $ | |
| 2 | Vaxcyte Inc | 11,474,599 | 666.8M $ | |
| 3 | Rhythm Pharmaceuticals Inc | 6,666,837 | 579.8M $ | |
| 4 | Tyra Biosciences Inc | 12,198,625 | 467.2M $ | |
| 5 | Sionna Therapeutics Inc | 9,905,045 | 397.1M $ | |
| 6 | Edgewise Therapeutics Inc | 10,428,437 | 328.5M $ | |
| 7 | Nuvalent Inc | 2,534,145 | 259.6M $ | |
| 8 | Dianthus Therapeutics Inc | 2,611,733 | 219.2M $ | |
| 9 | Mineralys Therapeutics Inc | 7,692,750 | 208.4M $ | |
| 10 | SpyGlass Pharma Inc | 8,021,117 | 207.8M $ | |
| 11 | Septerna Inc | 6,995,858 | 168.1M $ | |
| 12 | Disc Medicine Inc | 2,450,221 | 156.7M $ | |
| 13 | Janux Therapeutics Inc | 11,189,693 | 155.5M $ | |
| 14 | BioCryst Pharmaceuticals Inc | 15,827,186 | 150.7M $ | |
| 15 | Bicara Therapeutics Inc | 7,255,993 | 144.3M $ | |
| 16 | Praxis Precision Medicines Inc | 373,787 | 120.4M $ | |
| 17 | ZAI LAB LTD | 5,707,262 | 107.4M $ | |
| 18 | Taysha Gene Therapies Inc | 23,555,648 | 105.3M $ | |
| 19 | Vor BioPharma Inc | 5,404,998 | 96.4M $ | |
| 20 | Geron Corp | 63,771,366 | 95M $ | |
| 21 | ARS Pharmaceuticals Inc | 10,860,977 | 87.2M $ | |
| 22 | Sarepta Therapeutics Inc | 3,902,596 | 84.9M $ | |
| 23 | Spyre Therapeutics Inc | 1,621,620 | 81.8M $ | |
| 24 | Evommune Inc | 3,494,638 | 80.3M $ | |
| 25 | Climb Bio Inc | 11,300,939 | 77.4M $ | |
| 26 | Solid Biosciences Inc | 9,339,978 | 67.2M $ | |
| 27 | Artiva Biotherapeutics Inc | 9,853,302 | 63.5M $ | |
| 28 | DAMORA THERAPEUTICS INC | 2,399,310 | 62.1M $ | |
| 29 | Xencor Inc | 4,897,237 | 59.1M $ | |
| 30 | LB Pharmaceuticals Inc | 2,208,604 | 54.5M $ | |
| 31 | JADE BIOSCIENCES INC | 3,671,083 | 51.6M $ | |
| 32 | Acumen Pharmaceuticals Inc | 20,992,669 | 49.5M $ | |
| 33 | 4D Molecular Therapeutics Inc | 5,049,779 | 47M $ | |
| 34 | Fulcrum Therapeutics Inc | 6,053,960 | 46.4M $ | |
| 35 | Capricor Therapeutics Inc | 1,507,844 | 45.8M $ | |
| 36 | Century Therapeutics Inc | 17,754,430 | 40.1M $ | |
| 37 | Olema Pharmaceuticals Inc | 2,600,000 | 38.8M $ | |
| 38 | LENZ Therapeutics Inc | 4,178,823 | 38.2M $ | |
| 39 | Monopar Therapeutics Inc | 667,207 | 36.6M $ | |
| 40 | PepGen Inc | 20,064,545 | 35.5M $ | |
| 41 | Design Therapeutics Inc | 2,972,973 | 31.6M $ | |
| 42 | Mirum Pharmaceuticals Inc | 318,554 | 29.4M $ | |
| 43 | BioAge Labs Inc | 1,650,648 | 28.9M $ | |
| 44 | Lexeo Therapeutics Inc | 5,000,000 | 28.7M $ | |
| 45 | Assembly Biosciences Inc | 1,020,410 | 28.3M $ | |
| 46 | Rezolute Inc | 9,180,000 | 28M $ | |
| 47 | Aktis Oncology Inc | 1,503,084 | 26.9M $ | |
| 48 | ALX Oncology Holdings Inc | 13,011,849 | 26.1M $ | |
| 49 | Aclaris Therapeutics Inc | 6,804,072 | 25.5M $ | |
| 50 | Ovid therapeutics Inc | 10,714,000 | 23.8M $ | |
| 51 | Nkarta Inc | 10,805,129 | 22.8M $ | |
| 52 | Travere Therapeutics Inc | 746,841 | 22.2M $ | |
| 53 | GRAIL Inc | 428,266 | 22.1M $ | |
| 54 | C4 Therapeutics Inc | 8,000,000 | 21M $ | |
| 55 | Relmada Therapeutics Inc | 2,947,369 | 20.5M $ | |
| 56 | Benitec Biopharma Inc | 1,850,000 | 19.7M $ | |
| 57 | Sutro Biopharma Inc | 715,307 | 17.8M $ | |
| 58 | Contineum Therapeutics Inc | 1,296,012 | 16.9M $ | |
| 59 | SAB Biotherapeutics Inc | 4,401,500 | 16.9M $ | |
| 60 | Inspire Medical Systems Inc | 325,663 | 16.8M $ | |
| 61 | Anteris Technologies Global Corp | 3,000,000 | 16.7M $ | |
| 62 | OnKure Therapeutics Inc | 3,998,333 | 16.6M $ | |
| 63 | Hinge Health Inc | 364,613 | 14.1M $ | |
| 64 | GeneDx Holdings Corp | 209,887 | 13.5M $ | |
| 65 | Waystar Holding Corp | 529,400 | 12.8M $ | |
| 66 | Palisade Bio Inc | 7,124,116 | 12.5M $ | |
| 67 | Acrivon Therapeutics Inc | 8,340,508 | 11.6M $ | |
| 68 | Atrium Therapeutics Inc | 864,102 | 11.6M $ | |
| 69 | Karyopharm Therapeutics Inc | 1,917,354 | 10.7M $ | |
| 70 | AVALO THERAPEUTICS INC | 662,968 | 9.9M $ | |
| 71 | Adicet Bio Inc | 1,182,624 | 8.1M $ | |
| 72 | Corvus Pharmaceuticals Inc | 450,000 | 6.6M $ | |
| 73 | Rani Therapeutics Holdings Inc | 8,500,000 | 6.2M $ | |
| 74 | Equillium Inc | 3,096,336 | 6.2M $ | |
| 75 | WEREWOLF THERAPEUTICS INC | 6,681,307 | 5.6M $ | |
| 76 | MacroGenics Inc | 1,864,176 | 5.4M $ | |
| 77 | MapLight Therapeutics Inc | 248,294 | 5M $ | |
| 78 | PALATIN TECHNOLOGIES INC | 70,000 | 1.2M $ | |