Fund shareholders of Spyre Therapeutics Inc
ISIN US00773J2024 · United States · LEI 52990017AIJPRH3HQH40
- Fund shareholders
- 228
- Of which ETFs
- 41 187 other funds
- Value held
- 1.4B $ 33M SEK
- Share of capital
- 29.6 % of 88.2M shares on Jul 28, 2026
This issuer has other securities : Spyre Therapeutics, Inc. (US007CVR0207)
228 funds hold this company. This table lists the 227 that declare it in a regulatory filing. 1 more fund publishes its holdings in its own report. It is not in the table.
| Fund | Shares | Value | Weight in fund | Share of capital | |
|---|---|---|---|---|---|
| iShares Russell 3000 ETF iShares Trust | 19,760 | 996.7K $ | 0.01 % | 0.02 % | as of Mar 31, 2026 ↗ |
| Health Sciences Trust John Hancock Variable Insurance Trust | 19,484 | 982.8K $ | 0.43 % | 0.02 % | as of Mar 31, 2026 ↗ |
| Brighthouse/Wellington Large Cap Research Portfolio Brighthouse Funds Trust I | 19,129 | 964.9K $ | 0.04 % | 0.02 % | as of Mar 31, 2026 ↗ |
| ALGER HEALTH SCIENCES FUND ALGER FUNDS | 19,000 | 1.4M $ | 2.32 % | 0.02 % | as of Apr 30, 2026 ↗ |
| BIOTECHNOLOGY ULTRASECTOR PROFUND ProFunds | 18,961 | 1.4M $ | 0.77 % | 0.02 % | as of Apr 30, 2026 ↗ |
| Small-Cap Index Portfolio PACIFIC SELECT FUND | 17,971 | 906.5K $ | 0.12 % | 0.02 % | as of Mar 31, 2026 ↗ |
| VANGUARD RUSSELL 2000 VALUE INDEX FUND VANGUARD SCOTTSDALE FUNDS | 17,163 | 738.2K $ | 0.07 % | 0.02 % | as of Feb 28, 2026 ↗ |
| MML Small Cap Growth Equity Fund MML SERIES INVESTMENT FUND | 16,059 | 810K $ | 0.61 % | 0.02 % | as of Mar 31, 2026 ↗ |
| U.S. Small Cap Equity Fund RUSSELL INVESTMENT CO | 15,757 | 1.2M $ | 0.12 % | 0.02 % | as of Apr 30, 2026 ↗ |
| Schwab Small-Cap Equity Fund SCHWAB CAPITAL TRUST | 15,681 | 1.2M $ | 0.16 % | 0.02 % | as of Apr 30, 2026 ↗ |
| Diversified Equity Master Portfolio Master Investment Portfolio | 14,530 | 732.9K $ | 0.02 % | 0.02 % | as of Mar 31, 2026 ↗ |
| BlackRock Advantage Small Cap Growth Fund BlackRock Funds | 14,235 | 718K $ | 0.11 % | 0.02 % | as of Mar 31, 2026 ↗ |
| EQ/T.Rowe Price Health Sciences Portfolio EQ Advisors Trust | 13,859 | 699K $ | 0.44 % | 0.02 % | as of Mar 31, 2026 ↗ |
| NVIT Small Cap Index Fund Nationwide Variable Insurance Trust | 13,678 | 689.9K $ | 0.12 % | 0.02 % | as of Mar 31, 2026 ↗ |
| NYLIM VP Wellington Small Cap Portfolio NEW YORK LIFE INVESTMENTS VP FUNDS TRUST | 13,597 | 685.8K $ | 0.19 % | 0.02 % | as of Mar 31, 2026 ↗ |
| Small Cap Index Trust John Hancock Variable Insurance Trust | 12,492 | 630.1K $ | 0.11 % | 0.01 % | as of Mar 31, 2026 ↗ |
| T. Rowe Price Integrated U.S. Small-Mid Cap Core Equity Fund T. ROWE PRICE INTEGRATED EQUITY FUNDS, INC. | 11,913 | 600.9K $ | 0.04 % | 0.01 % | as of Mar 31, 2026 ↗ |
| iShares Russell Small/Mid-Cap Index Fund BlackRock Funds | 11,707 | 871.6K $ | 0.07 % | 0.01 % | as of Apr 30, 2026 ↗ |
| iShares Morningstar Small-Cap Growth ETF iShares Trust | 11,637 | 866.4K $ | 0.09 % | 0.01 % | as of Apr 30, 2026 ↗ |
| SIIT EXTENDED MARKET INDEX FUND SEI INSTITUTIONAL INVESTMENTS TRUST | 11,300 | 486K $ | 0.04 % | 0.01 % | as of Feb 28, 2026 ↗ |
| BlackRock Advantage Small Cap Core Fund BlackRock Funds | 10,711 | 460.7K $ | 0.01 % | 0.01 % | as of Feb 27, 2026 ↗ |
| Fidelity Flex Small Cap Index Fund Fidelity Salem Street Trust | 10,286 | 765.8K $ | 0.19 % | 0.01 % | as of Apr 30, 2026 ↗ |
| T. Rowe Price Extended Equity Market Index Fund T. ROWE PRICE INDEX TRUST, INC. | 10,142 | 511.6K $ | 0.05 % | 0.01 % | as of Mar 31, 2026 ↗ |
| Bridge Builder Small/Mid Cap Value Fund Bridge Builder Trust | 10,106 | 509.7K $ | 0.01 % | 0.01 % | as of Mar 31, 2026 ↗ |
| DWS Small Cap Index VIP DEUTSCHE DWS INVESTMENTS VIT FUNDS | 9,600 | 484.2K $ | 0.12 % | 0.01 % | as of Mar 31, 2026 ↗ |
| Goldman Sachs ActiveBeta(R) U.S. Small Cap Equity ETF Goldman Sachs ETF Trust | 8,967 | 385.7K $ | 0.04 % | 0.01 % | as of Feb 28, 2026 ↗ |
| Blackstone Alternative Multi-Strategy Fund Blackstone Alternative Investment Funds | 8,850 | 446.4K $ | 0.01 % | 0.01 % | as of Mar 31, 2026 ↗ |
| NYLI WMC Small Companies Fund NEW YORK LIFE INVESTMENTS FUNDS TRUST | 8,839 | 658.1K $ | 0.20 % | 0.01 % | as of Apr 30, 2026 ↗ |
| Bridge Builder Small/Mid Cap Growth Fund Bridge Builder Trust | 8,822 | 445K $ | 0.00 % | 0.01 % | as of Mar 31, 2026 ↗ |
| AST PGIM Aggressive Multi-Asset Portfolio Advanced Series Trust | 8,800 | 443.9K $ | 0.00 % | 0.01 % | as of Mar 31, 2026 ↗ |
| BlackRock Small Cap Index V.I. Fund BlackRock Variable Series Funds, Inc. | 8,489 | 428.2K $ | 0.12 % | 0.01 % | as of Mar 31, 2026 ↗ |
| Multi-Manager U.S. Small Cap Equity Fund Goldman Sachs Trust II | 8,343 | 621.1K $ | 0.18 % | 0.01 % | as of Apr 30, 2026 ↗ |
| T. Rowe Price Small-Cap Index Fund T. ROWE PRICE INDEX TRUST, INC. | 8,289 | 418.1K $ | 0.12 % | 0.01 % | as of Mar 31, 2026 ↗ |
| Virtus Biotech Clinical Trials Etf ETFis Series Trust I | 8,208 | 611.1K $ | 1.64 % | 0.01 % | as of Apr 30, 2026 ↗ |
| JPMorgan Small Cap Value Portfolio Brighthouse Funds Trust I | 8,156 | 411.4K $ | 0.13 % | 0.01 % | as of Mar 31, 2026 ↗ |
| SA Small Cap Index Portfolio SUNAMERICA SERIES TRUST | 8,016 | 596.8K $ | 0.17 % | 0.01 % | as of Apr 30, 2026 ↗ |
| Goldman Sachs Small Cap Equity Insights Fund Goldman Sachs Trust | 7,906 | 588.6K $ | 0.08 % | 0.01 % | as of Apr 30, 2026 ↗ |
| Carillon Chartwell Small Cap Fund Carillon Series Trust | 7,815 | 394.2K $ | 0.21 % | 0.01 % | as of Mar 31, 2026 ↗ |
| Victory Extended Market Index Fund Victory Portfolios III | 7,381 | 549.5K $ | 0.07 % | 0.01 % | as of Apr 30, 2026 ↗ |
| Voya RussellTM Small Cap Index Portfolio Voya VARIABLE PORTFOLIOS INC | 7,338 | 370.1K $ | 0.11 % | 0.01 % | as of Mar 31, 2026 ↗ |
| LVIP JPMorgan Small Cap Core Fund LINCOLN VARIABLE INSURANCE PRODUCTS TRUST | 7,274 | 366.9K $ | 0.18 % | 0.01 % | as of Mar 31, 2026 ↗ |
| AlphaCentric Life Sciences and Healthcare Fund MUTUAL FUND SERIES TRUST | 6,634 | 334.6K $ | 0.85 % | 0.01 % | as of Mar 31, 2026 ↗ |
| EQ/Morgan Stanley Small Cap Growth Portfolio EQ Advisors Trust | 6,210 | 313.2K $ | 0.08 % | 0.01 % | as of Mar 31, 2026 ↗ |
| Victory Pioneer Select Mid Cap Growth VCT Portfolio Victory Variable Insurance Funds II | 6,112 | 308.3K $ | 0.32 % | 0.01 % | as of Mar 31, 2026 ↗ |
| T. Rowe Price Total Equity Market Index Fund T. ROWE PRICE INDEX TRUST, INC. | 6,023 | 303.8K $ | 0.01 % | 0.01 % | as of Mar 31, 2026 ↗ |
| Nationwide Small Cap Index Fund Nationwide Mutual Funds | 5,910 | 440K $ | 0.17 % | 0.01 % | as of Apr 30, 2026 ↗ |
| PROFUND VP BIOTECHNOLOGY ProFunds | 5,850 | 295.1K $ | 0.71 % | 0.01 % | as of Mar 31, 2026 ↗ |
| Brighthouse/Wellington Balanced Portfolio Brighthouse Funds Trust II | 5,669 | 285.9K $ | 0.03 % | 0.01 % | as of Mar 31, 2026 ↗ |
| VANGUARD RUSSELL 3000 INDEX FUND VANGUARD SCOTTSDALE FUNDS | 5,643 | 242.7K $ | 0.00 % | 0.01 % | as of Feb 28, 2026 ↗ |
| CVT Russell 2000 Small Cap Index Portfolio Calvert Variable Trust, Inc. | 5,593 | 282.1K $ | 0.11 % | 0.01 % | as of Mar 31, 2026 ↗ |
| First Trust Multi-Manager Small Cap Opportunities ETF First Trust Exchange-Traded Fund VIII | 5,493 | 236.3K $ | 0.52 % | 0.01 % | as of Feb 28, 2026 ↗ |
| Carillon Chartwell Small Cap Growth Fund Carillon Series Trust | 5,274 | 266K $ | 0.21 % | 0.01 % | as of Mar 31, 2026 ↗ |
| Venerable Small Cap Index Fund Venerable Variable Insurance Trust | 5,237 | 264.2K $ | 0.12 % | 0.01 % | as of Mar 31, 2026 ↗ |
| iShares Morningstar Small-Cap Value ETF iShares Trust | 5,003 | 372.5K $ | 0.06 % | 0.01 % | as of Apr 30, 2026 ↗ |
| Invesco Russell 2000 Dynamic Multifactor ETF Invesco Exchange-Traded Self-Indexed Fund Trust | 4,922 | 211.7K $ | 0.08 % | 0.01 % | as of Feb 28, 2026 ↗ |
| Strategic Equity Allocation Trust John Hancock Variable Insurance Trust | 4,796 | 241.9K $ | 0.00 % | 0.01 % | as of Mar 31, 2026 ↗ |
| VY(R) JPMORGAN SMALL CAP CORE EQUITY PORTFOLIO Voya Investors Trust | 4,770 | 240.6K $ | 0.09 % | 0.01 % | as of Mar 31, 2026 ↗ |
| iShares Total U.S. Stock Market Index Fund BlackRock Funds | 4,592 | 341.9K $ | 0.01 % | 0.01 % | as of Apr 30, 2026 ↗ |
| VIP Extended Market Index Portfolio Variable Insurance Products Fund II | 4,582 | 231.1K $ | 0.05 % | 0.01 % | as of Mar 31, 2026 ↗ |
| Voya VACS Index Series SC Portfolio Voya VARIABLE PORTFOLIOS INC | 4,352 | 219.5K $ | 0.12 % | 0.00 % | as of Mar 31, 2026 ↗ |
| Invesco Nasdaq Biotechnology ETF Invesco Exchange-Traded Fund Trust II | 4,352 | 187.2K $ | 0.25 % | 0.00 % | as of Feb 28, 2026 ↗ |
| ProShares Ultra Russell2000 ProShares Trust | 4,251 | 182.8K $ | 0.06 % | 0.00 % | as of Feb 28, 2026 ↗ |
| ProShares UltraPro Russell2000 ProShares Trust | 4,235 | 182.1K $ | 0.05 % | 0.00 % | as of Feb 28, 2026 ↗ |
| FlexShares Morningstar US Market Factor Tilt Index Fund FlexShares Trust | 4,004 | 298.1K $ | 0.01 % | 0.00 % | as of Apr 30, 2026 ↗ |
| ProShares Ultra Nasdaq Biotechnology ProShares Trust | 3,583 | 154.1K $ | 0.17 % | 0.00 % | as of Feb 28, 2026 ↗ |
| AVIP BlackRock Advantage Small Cap Growth Portfolio AuguStar Variable Insurance Products Fund Inc | 3,558 | 179.5K $ | 0.15 % | 0.00 % | as of Mar 31, 2026 ↗ |
| First Trust Nasdaq Pharmaceuticals ETF First Trust Exchange-Traded Fund VI | 3,533 | 178.2K $ | 0.61 % | 0.00 % | as of Mar 31, 2026 ↗ |
| PD Small-Cap Growth Index Portfolio PACIFIC SELECT FUND | 3,428 | 172.9K $ | 0.15 % | 0.00 % | as of Mar 31, 2026 ↗ |
| 1290 VT Small Cap Value Portfolio EQ Advisors Trust | 3,395 | 171.2K $ | 0.04 % | 0.00 % | as of Mar 31, 2026 ↗ |
| iShares MSCI World Small-Cap ETF iShares Trust | 3,375 | 145.2K $ | 0.02 % | 0.00 % | as of Feb 28, 2026 ↗ |
| Morgan Stanley Pathway Small-Mid Cap Equity ETF MORGAN STANLEY PATHWAY FUNDS | 3,017 | 129.8K $ | 0.02 % | 0.00 % | as of Feb 28, 2026 ↗ |
| ProShares Russell 2000 High Income ETF ProShares Trust | 2,987 | 128.5K $ | 0.08 % | 0.00 % | as of Feb 28, 2026 ↗ |
| Small Cap Core Fund Northern Funds | 2,928 | 147.7K $ | 0.04 % | 0.00 % | as of Mar 31, 2026 ↗ |
| iShares Morningstar Small-Cap ETF iShares Trust | 2,792 | 207.9K $ | 0.08 % | 0.00 % | as of Apr 30, 2026 ↗ |
| Goldman Sachs Variable Insurance Trust Small Cap Equity Insights Fund Goldman Sachs Variable Insurance Trust | 2,484 | 125.3K $ | 0.07 % | 0.00 % | as of Mar 31, 2026 ↗ |
| EQ/Franklin Small Cap Value Managed Volatility Portfolio EQ Advisors Trust | 2,193 | 110.6K $ | 0.05 % | 0.00 % | as of Mar 31, 2026 ↗ |
| PGIM Balanced Fund Prudential Investment Portfolios, Inc. | 2,100 | 105.9K $ | 0.01 % | 0.00 % | as of Mar 31, 2026 ↗ |
| NVIT GS Small Cap Equity Insights Fund Nationwide Variable Insurance Trust | 2,056 | 103.7K $ | 0.05 % | 0.00 % | as of Mar 31, 2026 ↗ |
| PD Small-Cap Value Index Portfolio PACIFIC SELECT FUND | 1,927 | 97.2K $ | 0.08 % | 0.00 % | as of Mar 31, 2026 ↗ |
| Penn Series Small Cap Index Fund Penn Series Funds Inc | 1,900 | 95.8K $ | 0.12 % | 0.00 % | as of Mar 31, 2026 ↗ |
| Innovator U.S. Small Cap Managed Floor ETF Innovator ETFs Trust | 1,851 | 137.8K $ | 0.18 % | 0.00 % | as of Apr 30, 2026 ↗ |
| Allspring Disciplined Small Cap Fund ALLSPRING FUNDS TRUST | 1,709 | 86.2K $ | 0.06 % | 0.00 % | as of Mar 31, 2026 ↗ |
| Nationwide Fundamental All Cap Equity Portfolio Nationwide Mutual Funds | 1,656 | 123.3K $ | 0.01 % | 0.00 % | as of Apr 30, 2026 ↗ |
| State Street Total Return V.I.S. Fund STATE STREET VARIABLE INSURANCE SERIES FUNDS INC | 1,641 | 82.8K $ | 0.01 % | 0.00 % | as of Mar 31, 2026 ↗ |
| SA Multi-Managed Small Cap Portfolio SEASONS SERIES TRUST | 1,634 | 82.4K $ | 0.06 % | 0.00 % | as of Mar 31, 2026 ↗ |
| VIP Total Market Index Portfolio Variable Insurance Products Fund II | 1,629 | 82.2K $ | 0.01 % | 0.00 % | as of Mar 31, 2026 ↗ |
| Venerable US Small Cap Fund Venerable Variable Insurance Trust | 1,600 | 80.7K $ | 0.06 % | 0.00 % | as of Mar 31, 2026 ↗ |
| Eventide Small Cap ETF Strategy Shares | 1,513 | 112.6K $ | 0.44 % | 0.00 % | as of Apr 30, 2026 ↗ |
| JPMorgan Healthcare Leaders ETF J.P. Morgan Exchange-Traded Fund Trust | 1,327 | 98.8K $ | 0.89 % | 0.00 % | as of Apr 30, 2026 ↗ |
| Global Atlantic Wellington Research Managed Risk Portfolio Forethought Variable Insurance Trust | 1,309 | 66K $ | 0.03 % | 0.00 % | as of Mar 31, 2026 ↗ |
| Multimanager Aggressive Equity Portfolio EQ Advisors Trust | 1,300 | 65.6K $ | 0.00 % | 0.00 % | as of Mar 31, 2026 ↗ |
| Total Stock Market Index Trust John Hancock Variable Insurance Trust | 1,249 | 63K $ | 0.01 % | 0.00 % | as of Mar 31, 2026 ↗ |
| SIMT Multi-Asset Inflation Managed Fund SEI INSTITUTIONAL MANAGED TRUST | 1,213 | 61.2K $ | 0.01 % | 0.00 % | as of Mar 31, 2026 ↗ |
| AQR Small Cap Momentum Style Fund AQR Funds | 1,207 | 60.9K $ | 0.04 % | 0.00 % | as of Mar 31, 2026 ↗ |
| Small-Cap Equity Portfolio PACIFIC SELECT FUND | 1,002 | 50.5K $ | 0.02 % | 0.00 % | as of Mar 31, 2026 ↗ |
| ULTRA SMALL CAP PROFUND ProFunds | 842 | 62.7K $ | 0.11 % | 0.00 % | as of Apr 30, 2026 ↗ |
| TIAA Separate Account VA-1 - Stock Index Account TIAA Separate Account VA-1 | 830 | 41.9K $ | 0.00 % | 0.00 % | as of Mar 31, 2026 ↗ |
| Fidelity Small Cap Stock K6 Fund Fidelity Concord Street Trust | 817 | 60.8K $ | 0.33 % | 0.00 % | as of Apr 30, 2026 ↗ |
| SmallCap Value Fund II Principal Funds, Inc | 798 | 59.4K $ | 0.00 % | 0.00 % | as of Apr 30, 2026 ↗ |
| Fidelity Flex Small Cap Focused Index Fund Fidelity Salem Street Trust | 549 | 40.9K $ | 0.26 % | 0.00 % | as of Apr 30, 2026 ↗ |
The funds most exposed to it
The weight is the share of a fund's net assets. The holders table ranks funds by number of shares. This one ranks them by the weight of the company in each fund.
| Fund | Weight in fund | |
|---|---|---|
| F/m Emerald Life Sciences Innovation ETF RBB Fund, Inc. | 4.41 % | as of Feb 28, 2026 ↗ |
| Fidelity Advisor Biotechnology Fund Fidelity Advisor Series VII | 3.33 % | as of Apr 30, 2026 ↗ |
| Franklin Biotechnology Discovery Fund Franklin Strategic Series | 2.33 % | as of Apr 30, 2026 ↗ |
| ALGER HEALTH SCIENCES FUND ALGER FUNDS | 2.32 % | as of Apr 30, 2026 ↗ |
| ALPS Medical Breakthroughs ETF ALPS ETF TRUST | 2.15 % | as of Feb 28, 2026 ↗ |
| Virtus Biotech Clinical Trials Etf ETFis Series Trust I | 1.64 % | as of Apr 30, 2026 ↗ |
| Driehaus Micro Cap Growth Fund Driehaus Mutual Funds | 1.50 % | as of Mar 31, 2026 ↗ |
| Invesco Dorsey Wright Healthcare Momentum ETF Invesco Exchange-Traded Fund Trust | 1.49 % | as of Apr 30, 2026 ↗ |
| Victory RS Small Cap Growth Fund Victory Portfolios | 1.36 % | as of Mar 31, 2026 ↗ |
| Driehaus Small Cap Growth Fund Driehaus Mutual Funds | 1.23 % | as of Mar 31, 2026 ↗ |
Quarter after quarter
Each row is one quarter of SEC filings, newest first. The change compares each quarter with the one before.
| Quarter | Shareholders | Change | Shares | Change |
|---|---|---|---|---|
| 2026Q2 | 225 | +40 | 26,042,960 | +1.1 % |
| 2026Q1 | 185 | +11 | 25,756,005 | +29.0 % |
| 2025Q4 | 174 | +1 | 19,973,050 | +2.6 % |
| 2025Q3 | 173 | +6 | 19,461,233 | +3.1 % |
| 2025Q2 | 167 | +7 | 18,867,348 | +13.8 % |
| 2025Q1 | 160 | +12 | 16,573,727 | +30.6 % |
| 2024Q4 | 148 | +61 | 12,691,514 | +30.7 % |
| 2024Q3 | 87 | +44 | 9,708,791 | +87.7 % |
| 2024Q2 | 43 | +24 | 5,173,281 | +257.3 % |
| 2024Q1 | 19 | +15 | 1,447,899 | +3,730.1 % |
| 2023Q4 | 4 | 37,803 |
Institutional managers
189 managers declare this company to the SEC (Form 13F). The table shows the 25 largest.
| Manager | Shares | Value | |
|---|---|---|---|
| FMR LLC | 11,781,024 | 594.2M $ | as of Mar 31, 2026 |
| BlackRock, Inc. | 5,521,221 | 278.5M $ | as of Mar 31, 2026 |
| RTW INVESTMENTS, LP | 4,171,996 | 210.4M $ | as of Mar 31, 2026 |
| Fairmount Funds Management LLC | 4,018,101 | 202.7M $ | as of Mar 31, 2026 |
| PERCEPTIVE ADVISORS LLC | 3,783,225 | 190.8M $ | as of Mar 31, 2026 |
| Venrock Adviser, LLC | 3,685,448 | 185.9M $ | as of Mar 31, 2026 |
| Driehaus Capital Management LLC | 2,790,785 | 140.8M $ | as of Mar 31, 2026 |
| STATE STREET CORP | 2,607,031 | 131.5M $ | as of Mar 31, 2026 |
| Paradigm Biocapital Advisors LP | 1,957,266 | 98.7M $ | as of Mar 31, 2026 |
| Commodore Capital LP | 1,912,380 | 96.5M $ | as of Mar 31, 2026 |
| TCG Crossover Management, LLC | 1,900,582 | 95.9M $ | as of Mar 31, 2026 |
| TANG CAPITAL MANAGEMENT LLC | 1,892,200 | 95.4M $ | as of Mar 31, 2026 |
| WELLINGTON MANAGEMENT GROUP LLP | 1,824,811 | 92M $ | as of Mar 31, 2026 |
| Capital International Investors | 1,746,129 | 88.1M $ | as of Mar 31, 2026 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,720,912 | 86.8M $ | as of Mar 31, 2026 |
| JANUS HENDERSON GROUP PLC | 1,656,164 | 83.6M $ | as of Mar 31, 2026 |
| RA CAPITAL MANAGEMENT, L.P. | 1,621,620 | 81.8M $ | as of Mar 31, 2026 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,598,730 | 80.6K $ | as of Mar 31, 2026 |
| Remedium Capital Partners, LLC | 1,456,231 | 73.5M $ | as of Mar 31, 2026 |
| Affinity Asset Advisors, LLC | 1,279,134 | 64.5M $ | as of Mar 31, 2026 |
| BANK OF AMERICA CORP /DE/ | 1,228,093 | 61.9M $ | as of Mar 31, 2026 |
| BAKER BROS. ADVISORS LP | 1,000,000 | 50.4M $ | as of Mar 31, 2026 |
| JPMORGAN CHASE & CO | 979,299 | 44.5M $ | as of Mar 31, 2026 |
| BRAIDWELL LP | 932,823 | 47.1M $ | as of Mar 31, 2026 |
| FRANKLIN RESOURCES INC | 882,833 | 44.5M $ | as of Mar 31, 2026 |
Declared shareholders of Spyre Therapeutics Inc
There are 2 beneficial ownership filings. These stakes do not add up. An asset manager that files includes its own funds, which already appear among the funds on this page.
| Shareholder | Declared stake | Shares | |
|---|---|---|---|
| Fairmount Funds Management LLC and 3 others | 9.99 % | 9,667,201 | as of Jun 23, 2026 · SCHEDULE 13D |
| Perceptive Advisors LLC and 2 others | 5.00 % | 4,319,496 | as of Apr 15, 2026 · SCHEDULE 13G |
Cite this page
Titelia. "Fund shareholders of Spyre Therapeutics Inc". https://titelia.com/en/stocks/spyre-therapeutics-inc-US00773J2024