Fund shareholders of Spyre Therapeutics Inc
ISIN US00773J2024 · United States · LEI 52990017AIJPRH3HQH40
- Fund shareholders
- 228
- Of which ETFs
- 41 187 other funds
- Value held
- 1.4B $ 33M SEK
- Share of capital
- 29.6 % of 88.2M shares on Jul 28, 2026
This issuer has other securities : Spyre Therapeutics, Inc. (US007CVR0207)
228 funds hold this company. This table lists the 227 that declare it in a regulatory filing. 1 more fund publishes its holdings in its own report. It is not in the table.
| Fund | Shares | Value | Weight in fund | Share of capital | |
|---|---|---|---|---|---|
| Nuveen Life Stock Index Fund TIAA-CREF Life Funds | 538 | 27.1K $ | 0.00 % | 0.00 % | as of Mar 31, 2026 ↗ |
| Goldman Sachs Small Cap Growth Insights Fund Goldman Sachs Trust | 517 | 38.5K $ | 0.01 % | 0.00 % | as of Apr 30, 2026 ↗ |
| T. Rowe Price Innovation Leaders ETF T. Rowe Price Exchange-Traded Funds, Inc. | 480 | 24.2K $ | 0.16 % | 0.00 % | as of Mar 31, 2026 ↗ |
| Small Company Value Portfolio Wilshire Mutual Funds Inc | 450 | 22.7K $ | 0.10 % | 0.00 % | as of Mar 31, 2026 ↗ |
| Knights of Columbus U.S. ALL CAP INDEX FUND ADVISORS' INNER CIRCLE III | 369 | 27.5K $ | 0.01 % | 0.00 % | as of Apr 30, 2026 ↗ |
| Wilshire 5000 Index Fund Wilshire Mutual Funds Inc | 352 | 17.8K $ | 0.01 % | 0.00 % | as of Mar 31, 2026 ↗ |
| Russell 2000 2x Strategy Fund Rydex Dynamic Funds | 342 | 17.3K $ | 0.03 % | 0.00 % | as of Mar 31, 2026 ↗ |
| State Street(R) SPDR(R) Portfolio MSCI Global Stock Market ETF SPDR INDEX SHARES FUNDS | 305 | 15.4K $ | 0.00 % | 0.00 % | as of Mar 31, 2026 ↗ |
| State Street Balanced Index Fund STATE STREET INSTITUTIONAL INVESTMENT TRUST | 305 | 15.4K $ | 0.00 % | 0.00 % | as of Mar 31, 2026 ↗ |
| Innovator U.S. Small Cap Managed 10 Buffer ETF Innovator ETFs Trust | 240 | 17.9K $ | 0.23 % | 0.00 % | as of Apr 30, 2026 ↗ |
| PROFUND VP ULTRA SMALL CAP ProFunds | 230 | 11.6K $ | 0.08 % | 0.00 % | as of Mar 31, 2026 ↗ |
| Goldman Sachs Absolute Return Tracker Fund GOLDMAN SACHS TRUST | 224 | 11.3K $ | 0.00 % | 0.00 % | as of Mar 31, 2026 ↗ |
| Gotham Absolute Return Fund FundVantage Trust | 191 | 9.6K $ | 0.00 % | 0.00 % | as of Mar 31, 2026 ↗ |
| PROFUND VP SMALL CAP ProFunds | 174 | 8.8K $ | 0.07 % | 0.00 % | as of Mar 31, 2026 ↗ |
| Russell 2000 Fund Rydex Series Funds | 157 | 7.9K $ | 0.06 % | 0.00 % | as of Mar 31, 2026 ↗ |
| SMALL-CAP PROFUND ProFunds | 136 | 10.1K $ | 0.13 % | 0.00 % | as of Apr 30, 2026 ↗ |
| E*TRADE No Fee Total Market Index Fund E Trade Trust | 134 | 10K $ | 0.01 % | 0.00 % | as of Apr 30, 2026 ↗ |
| Small Company Growth Portfolio Wilshire Mutual Funds Inc | 125 | 6.3K $ | 0.03 % | 0.00 % | as of Mar 31, 2026 ↗ |
| Russell 2000 1.5x Strategy Fund Rydex Series Funds | 94 | 4.7K $ | 0.08 % | 0.00 % | as of Mar 31, 2026 ↗ |
| Fidelity Series Sustainable U.S. Market Fund Fidelity Summer Street Trust | 93 | 6.9K $ | 0.01 % | 0.00 % | as of Apr 30, 2026 ↗ |
| ProShares Hedge Replication ETF ProShares Trust | 71 | 3.1K $ | 0.01 % | 0.00 % | as of Feb 28, 2026 ↗ |
| Columbia Research Enhanced Small Cap ETF Columbia ETF Trust I | 68 | 3.4K $ | 0.11 % | 0.00 % | as of Mar 31, 2026 ↗ |
| Gotham Enhanced Return Fund FundVantage Trust | 59 | 3K $ | 0.00 % | 0.00 % | as of Mar 31, 2026 ↗ |
| Gotham Neutral Fund FundVantage Trust | 58 | 2.9K $ | 0.00 % | 0.00 % | as of Mar 31, 2026 ↗ |
| Goldman Sachs MSCI World Private Equity Return Tracker ETF Goldman Sachs ETF Trust | 23 | 989.2 $ | 0.00 % | 0.00 % | as of Feb 28, 2026 ↗ |
| ProShares Russell 2000 Dynamic Buffer ETF ProShares Trust | 22 | 946.2 $ | 0.08 % | 0.00 % | as of Feb 28, 2026 ↗ |
| Russell 2000(R) 1.5x Strategy Fund Rydex Variable Trust | 18 | 907.9 $ | 0.03 % | 0.00 % | as of Mar 31, 2026 ↗ |
The funds most exposed to it
The weight is the share of a fund's net assets. The holders table ranks funds by number of shares. This one ranks them by the weight of the company in each fund.
| Fund | Weight in fund | |
|---|---|---|
| F/m Emerald Life Sciences Innovation ETF RBB Fund, Inc. | 4.41 % | as of Feb 28, 2026 ↗ |
| Fidelity Advisor Biotechnology Fund Fidelity Advisor Series VII | 3.33 % | as of Apr 30, 2026 ↗ |
| Franklin Biotechnology Discovery Fund Franklin Strategic Series | 2.33 % | as of Apr 30, 2026 ↗ |
| ALGER HEALTH SCIENCES FUND ALGER FUNDS | 2.32 % | as of Apr 30, 2026 ↗ |
| ALPS Medical Breakthroughs ETF ALPS ETF TRUST | 2.15 % | as of Feb 28, 2026 ↗ |
| Virtus Biotech Clinical Trials Etf ETFis Series Trust I | 1.64 % | as of Apr 30, 2026 ↗ |
| Driehaus Micro Cap Growth Fund Driehaus Mutual Funds | 1.50 % | as of Mar 31, 2026 ↗ |
| Invesco Dorsey Wright Healthcare Momentum ETF Invesco Exchange-Traded Fund Trust | 1.49 % | as of Apr 30, 2026 ↗ |
| Victory RS Small Cap Growth Fund Victory Portfolios | 1.36 % | as of Mar 31, 2026 ↗ |
| Driehaus Small Cap Growth Fund Driehaus Mutual Funds | 1.23 % | as of Mar 31, 2026 ↗ |
Quarter after quarter
Each row is one quarter of SEC filings, newest first. The change compares each quarter with the one before.
| Quarter | Shareholders | Change | Shares | Change |
|---|---|---|---|---|
| 2026Q2 | 225 | +40 | 26,042,960 | +1.1 % |
| 2026Q1 | 185 | +11 | 25,756,005 | +29.0 % |
| 2025Q4 | 174 | +1 | 19,973,050 | +2.6 % |
| 2025Q3 | 173 | +6 | 19,461,233 | +3.1 % |
| 2025Q2 | 167 | +7 | 18,867,348 | +13.8 % |
| 2025Q1 | 160 | +12 | 16,573,727 | +30.6 % |
| 2024Q4 | 148 | +61 | 12,691,514 | +30.7 % |
| 2024Q3 | 87 | +44 | 9,708,791 | +87.7 % |
| 2024Q2 | 43 | +24 | 5,173,281 | +257.3 % |
| 2024Q1 | 19 | +15 | 1,447,899 | +3,730.1 % |
| 2023Q4 | 4 | 37,803 |
Institutional managers
189 managers declare this company to the SEC (Form 13F). The table shows the 25 largest.
| Manager | Shares | Value | |
|---|---|---|---|
| FMR LLC | 11,781,024 | 594.2M $ | as of Mar 31, 2026 |
| BlackRock, Inc. | 5,521,221 | 278.5M $ | as of Mar 31, 2026 |
| RTW INVESTMENTS, LP | 4,171,996 | 210.4M $ | as of Mar 31, 2026 |
| Fairmount Funds Management LLC | 4,018,101 | 202.7M $ | as of Mar 31, 2026 |
| PERCEPTIVE ADVISORS LLC | 3,783,225 | 190.8M $ | as of Mar 31, 2026 |
| Venrock Adviser, LLC | 3,685,448 | 185.9M $ | as of Mar 31, 2026 |
| Driehaus Capital Management LLC | 2,790,785 | 140.8M $ | as of Mar 31, 2026 |
| STATE STREET CORP | 2,607,031 | 131.5M $ | as of Mar 31, 2026 |
| Paradigm Biocapital Advisors LP | 1,957,266 | 98.7M $ | as of Mar 31, 2026 |
| Commodore Capital LP | 1,912,380 | 96.5M $ | as of Mar 31, 2026 |
| TCG Crossover Management, LLC | 1,900,582 | 95.9M $ | as of Mar 31, 2026 |
| TANG CAPITAL MANAGEMENT LLC | 1,892,200 | 95.4M $ | as of Mar 31, 2026 |
| WELLINGTON MANAGEMENT GROUP LLP | 1,824,811 | 92M $ | as of Mar 31, 2026 |
| Capital International Investors | 1,746,129 | 88.1M $ | as of Mar 31, 2026 |
| GEODE CAPITAL MANAGEMENT, LLC | 1,720,912 | 86.8M $ | as of Mar 31, 2026 |
| JANUS HENDERSON GROUP PLC | 1,656,164 | 83.6M $ | as of Mar 31, 2026 |
| RA CAPITAL MANAGEMENT, L.P. | 1,621,620 | 81.8M $ | as of Mar 31, 2026 |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,598,730 | 80.6K $ | as of Mar 31, 2026 |
| Remedium Capital Partners, LLC | 1,456,231 | 73.5M $ | as of Mar 31, 2026 |
| Affinity Asset Advisors, LLC | 1,279,134 | 64.5M $ | as of Mar 31, 2026 |
| BANK OF AMERICA CORP /DE/ | 1,228,093 | 61.9M $ | as of Mar 31, 2026 |
| BAKER BROS. ADVISORS LP | 1,000,000 | 50.4M $ | as of Mar 31, 2026 |
| JPMORGAN CHASE & CO | 979,299 | 44.5M $ | as of Mar 31, 2026 |
| BRAIDWELL LP | 932,823 | 47.1M $ | as of Mar 31, 2026 |
| FRANKLIN RESOURCES INC | 882,833 | 44.5M $ | as of Mar 31, 2026 |
Declared shareholders of Spyre Therapeutics Inc
There are 2 beneficial ownership filings. These stakes do not add up. An asset manager that files includes its own funds, which already appear among the funds on this page.
| Shareholder | Declared stake | Shares | |
|---|---|---|---|
| Fairmount Funds Management LLC and 3 others | 9.99 % | 9,667,201 | as of Jun 23, 2026 · SCHEDULE 13D |
| Perceptive Advisors LLC and 2 others | 5.00 % | 4,319,496 | as of Apr 15, 2026 · SCHEDULE 13G |
Cite this page
Titelia. "Fund shareholders of Spyre Therapeutics Inc". https://titelia.com/en/stocks/spyre-therapeutics-inc-US00773J2024