Holdings of State Street(R) SPDR(R) S&P(R) Biotech ETF
SPDR SERIES TRUST · 147 declared positions · as of Mar 31, 2026
Original filing · Net assets 7.4B $ · Ten largest lines: 13.7 % of the equity sleeve
Country breakdown
Shares computed on the equity sleeve, the only part this site carries.
| Country | Lines | Value (USD) | Share |
|---|---|---|---|
| US | 141 | 7.1B $ | 95.45 % |
| IE | 2 | 117.4M $ | 1.58 % |
| CH | 1 | 80.7M $ | 1.09 % |
| BM | 1 | 79.3M $ | 1.07 % |
| VG | 1 | 32.5M $ | 0.44 % |
| NL | 1 | 27.8M $ | 0.37 % |
Sector breakdown is published in no regulatory filing: neither Form N-PORT nor the LEI reference data carries an activity code. It is absent rather than estimated.
Positions
| Company | Shares | Value (USD) | Weight |
|---|---|---|---|
| Apellis Pharmaceuticals Inc | 3,390,454 | 136.4M $ | 1.83 % |
| Alkermes PLC | 3,050,830 | 107.9M $ | 1.45 % |
| Madrigal Pharmaceuticals Inc | 196,408 | 102.8M $ | 1.38 % |
| TG Therapeutics Inc | 3,020,301 | 100.3M $ | 1.35 % |
| Insmed Inc | 607,845 | 99.4M $ | 1.34 % |
| Scholar Rock Holding Corp | 1,961,965 | 96.5M $ | 1.30 % |
| Apogee Therapeutics Inc | 1,134,394 | 95.5M $ | 1.28 % |
| Protagonist Therapeutics Inc | 878,071 | 92.5M $ | 1.24 % |
| Summit Therapeutics Inc | 4,866,448 | 92.3M $ | 1.24 % |
| United Therapeutics Corp | 155,530 | 92.2M $ | 1.24 % |
| Praxis Precision Medicines Inc | 285,252 | 91.9M $ | 1.24 % |
| Arrowhead Pharmaceuticals Inc | 1,458,207 | 91.4M $ | 1.23 % |
| Cogent Biosciences Inc | 2,348,101 | 90.4M $ | 1.22 % |
| Bridgebio Pharma Inc | 1,186,816 | 88.1M $ | 1.19 % |
| PTC Therapeutics Inc | 1,290,071 | 87.9M $ | 1.18 % |
| Cytokinetics Inc | 1,331,453 | 87.8M $ | 1.18 % |
| Alnylam Pharmaceuticals Inc | 264,406 | 87.5M $ | 1.18 % |
| Exelixis Inc | 2,029,215 | 87M $ | 1.17 % |
| Nuvalent Inc | 846,768 | 86.8M $ | 1.17 % |
| Kymera Therapeutics Inc | 1,039,280 | 86.6M $ | 1.16 % |
| CG oncology Inc | 1,276,920 | 86.4M $ | 1.16 % |
| Natera Inc | 430,933 | 86.2M $ | 1.16 % |
| Neurocrine Biosciences Inc | 654,044 | 86.2M $ | 1.16 % |
| Twist Bioscience Corp | 1,808,036 | 85.9M $ | 1.16 % |
| Krystal Biotech Inc | 332,277 | 85.8M $ | 1.15 % |
| Vaxcyte Inc | 1,472,715 | 85.6M $ | 1.15 % |
| Mirum Pharmaceuticals Inc | 923,473 | 85.3M $ | 1.15 % |
| Amicus Therapeutics Inc | 5,895,670 | 85.3M $ | 1.15 % |
| Ionis Pharmaceuticals Inc | 1,132,906 | 85.1M $ | 1.14 % |
| Travere Therapeutics Inc | 2,863,192 | 85.1M $ | 1.14 % |
| Arcellx Inc | 740,785 | 85.1M $ | 1.14 % |
| Regeneron Pharmaceuticals, Inc. | 109,400 | 84.5M $ | 1.14 % |
| Incyte Corp | 895,013 | 84.2M $ | 1.13 % |
| Celcuity Inc | 731,925 | 83.5M $ | 1.12 % |
| Revolution Medicines Inc | 850,768 | 82.7M $ | 1.11 % |
| Halozyme Therapeutics Inc | 1,274,489 | 82.4M $ | 1.11 % |
| Rhythm Pharmaceuticals Inc | 941,162 | 81.9M $ | 1.10 % |
| Biogen Inc | 444,855 | 81.6M $ | 1.10 % |
| Arcutis Biotherapeutics Inc | 3,437,805 | 81M $ | 1.09 % |
| AbbVie Inc | 372,103 | 80.9M $ | 1.09 % |
| Gilead Sciences Inc | 580,264 | 80.9M $ | 1.09 % |
| CRISPR Therapeutics AG | 1,696,801 | 80.7M $ | 1.09 % |
| BioMarin Pharmaceutical Inc | 1,404,601 | 79.3M $ | 1.07 % |
| Roivant Sciences Ltd | 2,864,237 | 79.3M $ | 1.07 % |
| Amgen Inc | 224,546 | 79M $ | 1.06 % |
| ImmunityBio Inc | 10,244,025 | 78.6M $ | 1.06 % |
| Beam Therapeutics Inc | 3,248,626 | 77.4M $ | 1.04 % |
| Viking Therapeutics Inc | 2,369,189 | 77.1M $ | 1.04 % |
| Vera Therapeutics Inc | 1,912,054 | 76.9M $ | 1.03 % |
| Moderna Inc | 1,513,720 | 76.9M $ | 1.03 % |
| Vertex Pharmaceuticals Inc | 172,078 | 76.8M $ | 1.03 % |
| Erasca Inc | 4,733,094 | 76.6M $ | 1.03 % |
| ACADIA Pharmaceuticals Inc | 3,412,655 | 76M $ | 1.02 % |
| Sarepta Therapeutics Inc | 3,057,030 | 66.5M $ | 0.89 % |
| Agios Pharmaceuticals Inc | 1,930,324 | 65.3M $ | 0.88 % |
| Ultragenyx Pharmaceutical Inc | 3,107,837 | 65.1M $ | 0.88 % |
| Disc Medicine Inc | 1,012,048 | 64.7M $ | 0.87 % |
| Immunome Inc | 2,934,802 | 64.2M $ | 0.86 % |
| Immunovant Inc | 2,566,528 | 63.8M $ | 0.86 % |
| BioCryst Pharmaceuticals Inc | 6,655,054 | 63.4M $ | 0.85 % |
| Veracyte Inc | 1,957,681 | 63.1M $ | 0.85 % |
| Dyne Therapeutics Inc | 3,437,524 | 62.3M $ | 0.84 % |
| Catalyst Pharmaceuticals Inc | 2,268,292 | 56.2M $ | 0.76 % |
| Syndax Pharmaceuticals Inc | 2,343,191 | 54.7M $ | 0.74 % |
| Denali Therapeutics Inc | 2,830,854 | 54.4M $ | 0.73 % |
| Ideaya Biosciences Inc | 1,628,726 | 54.3M $ | 0.73 % |
| Spyre Therapeutics Inc | 1,069,556 | 53.9M $ | 0.73 % |
| GRAIL Inc | 1,041,295 | 53.8M $ | 0.72 % |
| Viridian Therapeutics Inc | 2,667,007 | 52.2M $ | 0.70 % |
| Recursion Pharmaceuticals Inc | 16,732,511 | 51.4M $ | 0.69 % |
| Kodiak Sciences Inc | 1,344,151 | 51.2M $ | 0.69 % |
| Soleno Therapeutics Inc | 1,496,078 | 50.1M $ | 0.67 % |
| Dianthus Therapeutics Inc | 586,673 | 49.2M $ | 0.66 % |
| Intellia Therapeutics Inc | 3,753,333 | 48.1M $ | 0.65 % |
| Mineralys Therapeutics Inc | 1,773,248 | 48M $ | 0.65 % |
| Arcus Biosciences Inc | 2,163,363 | 46.7M $ | 0.63 % |
| Ardelyx Inc | 7,664,448 | 45.9M $ | 0.62 % |
| ADMA Biologics Inc | 4,916,092 | 44.3M $ | 0.60 % |
| Nurix Therapeutics Inc | 2,809,877 | 43.6M $ | 0.59 % |
| Tango Therapeutics Inc | 1,972,571 | 41.3M $ | 0.56 % |
| Celldex Therapeutics Inc | 1,222,480 | 38.8M $ | 0.52 % |
| Novavax Inc | 4,667,715 | 38M $ | 0.51 % |
| Oruka Therapeutics Inc | 761,033 | 37.3M $ | 0.50 % |
| Olema Pharmaceuticals Inc | 2,471,879 | 36.9M $ | 0.50 % |
| Stoke Therapeutics Inc | 1,125,672 | 36.7M $ | 0.49 % |
| Vericel Corp | 1,116,252 | 35.9M $ | 0.48 % |
| Capricor Therapeutics Inc | 1,171,894 | 35.6M $ | 0.48 % |
| Palvella Therapeutics Inc | 274,232 | 34.2M $ | 0.46 % |
| Biohaven Ltd | 3,844,682 | 32.5M $ | 0.44 % |
| Monte Rosa Therapeutics Inc | 1,966,731 | 32.4M $ | 0.44 % |
| Corvus Pharmaceuticals Inc | 2,116,858 | 31M $ | 0.42 % |
| Iovance Biotherapeutics Inc | 8,139,873 | 28.6M $ | 0.38 % |
| AnaptysBio Inc | 512,175 | 28.4M $ | 0.38 % |
| Relay Therapeutics Inc | 2,831,639 | 28.2M $ | 0.38 % |
| uniQure NV | 1,697,402 | 27.8M $ | 0.37 % |
| ORIC Pharmaceuticals Inc | 2,171,512 | 27.5M $ | 0.37 % |
| MannKind Corp | 10,933,657 | 26.8M $ | 0.36 % |
| CareDx Inc | 1,480,419 | 25.7M $ | 0.35 % |
| Taysha Gene Therapies Inc | 5,638,911 | 25.2M $ | 0.34 % |
| Tyra Biosciences Inc | 655,457 | 25.1M $ | 0.34 % |
| Geron Corp | 16,613,693 | 24.8M $ | 0.33 % |
| Day One Biopharmaceuticals Inc | 1,113,401 | 23.9M $ | 0.32 % |
| Precigen Inc | 6,004,794 | 23.2M $ | 0.31 % |
| Vir Biotechnology Inc | 2,527,795 | 22.6M $ | 0.30 % |
| KalVista Pharmaceuticals Inc | 1,077,952 | 21.7M $ | 0.29 % |
| CytomX Therapeutics Inc | 4,511,036 | 21.2M $ | 0.29 % |
| Annexon Inc | 3,823,368 | 21.2M $ | 0.28 % |
| Kura Oncology Inc | 2,523,230 | 20.5M $ | 0.28 % |
| Inhibrx Biosciences Inc | 296,581 | 19.9M $ | 0.27 % |
| SELLAS Life Sciences Group Inc | 4,689,810 | 19.8M $ | 0.27 % |
| Janux Therapeutics Inc | 1,424,540 | 19.8M $ | 0.27 % |
| Compass Therapeutics Inc | 3,684,989 | 19.5M $ | 0.26 % |
| Savara Inc | 3,554,970 | 19.4M $ | 0.26 % |
| Rigel Pharmaceuticals Inc | 708,776 | 19.2M $ | 0.26 % |
| Sana Biotechnology Inc | 6,650,475 | 19.2M $ | 0.26 % |
| Cullinan Therapeutics Inc | 1,307,461 | 18.6M $ | 0.25 % |
| ARS Pharmaceuticals Inc | 2,213,506 | 17.8M $ | 0.24 % |
| ZENAS BIOPHARMA INC | 906,255 | 17.7M $ | 0.24 % |
| Xencor Inc | 1,422,163 | 17.2M $ | 0.23 % |
| Replimune Group Inc | 2,198,386 | 16.8M $ | 0.23 % |
| Sionna Therapeutics Inc | 416,630 | 16.7M $ | 0.22 % |
| Vor BioPharma Inc | 932,400 | 16.6M $ | 0.22 % |
| ArriVent Biopharma Inc | 701,088 | 16.2M $ | 0.22 % |
| Ironwood Pharmaceuticals Inc | 3,999,224 | 14M $ | 0.19 % |
| Bicara Therapeutics Inc | 701,643 | 14M $ | 0.19 % |
| Prime Medicine Inc | 3,979,993 | 13.9M $ | 0.19 % |
| Altimmune Inc | 4,353,091 | 13.4M $ | 0.18 % |
| Absci Corp | 4,448,453 | 13.3M $ | 0.18 % |
| Emergent BioSolutions Inc | 1,572,925 | 13.1M $ | 0.18 % |
| Allogene Therapeutics Inc | 5,212,606 | 12.7M $ | 0.17 % |
| HYPERLIQUID STRATEGIES INC | 2,451,336 | 12.5M $ | 0.17 % |
| 4D Molecular Therapeutics Inc | 1,318,068 | 12.3M $ | 0.17 % |
| Vanda Pharmaceuticals Inc | 1,704,031 | 11.8M $ | 0.16 % |
| REGENXBIO Inc | 1,363,810 | 11.4M $ | 0.15 % |
| Lexeo Therapeutics Inc | 1,862,707 | 10.7M $ | 0.14 % |
| Verastem Inc | 2,014,499 | 10.7M $ | 0.14 % |
| Arbutus Biopharma Corp | 2,268,065 | 10.2M $ | 0.14 % |
| Myriad Genetics Inc | 2,160,321 | 9.7M $ | 0.13 % |
| Prothena Corp PLC | 983,448 | 9.6M $ | 0.13 % |
| Ocugen Inc | 5,222,819 | 9.5M $ | 0.13 % |
| Rocket Pharmaceuticals Inc | 2,606,982 | 9.3M $ | 0.13 % |
| MiMedx Group Inc | 2,282,660 | 9M $ | 0.12 % |
| Akebia Therapeutics Inc | 6,038,997 | 8.4M $ | 0.11 % |
| Anavex Life Sciences Corp | 2,653,883 | 8.1M $ | 0.11 % |
| Invivyd Inc | 5,654,625 | 7.4M $ | 0.10 % |
| Perspective Therapeutics Inc | 1,713,495 | 7.1M $ | 0.10 % |
| DAMORA THERAPEUTICS INC | 93,797 | 2.4M $ | 0.03 % |