Titelia

Holdings of SPHERA FUNDS MANAGEMENT LTD.

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Net assets
-
Positions
76 in 5 countries
Top ten
41.2 % of the equity sleeve
Filed on
Mar 31, 2026
Portfolio shape

Positions

RankCompanySharesValueWeight
1Mineralys Therapeutics Inc 1,339,97136.3M $
2Teva Pharmaceutical Industries Ltd 1,136,97534.2M $
3Bridgebio Pharma Inc 245,24618.2M $
4Biogen Inc 92,52617M $
5Ultragenyx Pharmaceutical Inc 809,33317M $
6Syndax Pharmaceuticals Inc 724,56316.9M $
7COGENT BIOSCIENCES INC 416,34016M $
8SANOFI SA 269,51513M $
9Amicus Therapeutics Inc 603,3778.7M $
10Apellis Pharmaceuticals Inc 214,9148.6M $
11Palo Alto Networks Inc 52,8008.5M $
12Eli Lilly & Co 9,0408.3M $
13BioCryst Pharmaceuticals Inc 866,4648.2M $
14BioMarin Pharmaceutical Inc 139,9007.9M $
15Celldex Therapeutics Inc 243,5757.7M $
16Ormat Technologies Inc 68,2507.6M $
17Soleno Therapeutics Inc 216,2817.2M $
18Tango Therapeutics Inc 343,5637.2M $
19Johnson & Johnson 28,8317M $
20Trevi Therapeutics Inc 574,0296.8M $
21ORIC Pharmaceuticals Inc 537,6286.8M $
22Maze Therapeutics Inc 227,3436.8M $
23GSK PLC 122,0006.7M $
24Amazon.com Inc 31,9406.7M $
25AbbVie Inc 30,2566.6M $
26Applied Optoelectronics Inc 73,4006.2M $
27Enliven Therapeutics Inc 153,2656M $
28Merck & Co Inc 48,6005.8M $
29VOR BIOPHARMA INC 321,9175.7M $
30ACADIA Pharmaceuticals Inc 256,2025.7M $
31Novartis AG 37,0005.7M $
32Eledon Pharmaceuticals Inc 1,772,1315.5M $
33Enphase Energy Inc 142,4195.4M $
34REVOLUTION MEDICINES INC 55,1105.4M $
35Pfizer Inc 186,0005.2M $
36Forte Biosciences Inc 184,9844.8M $
37Madrigal Pharmaceuticals Inc 9,0404.7M $
38Scholar Rock Holding Corp 94,2654.6M $
39Novo Nordisk A/S 120,6774.4M $
40Kodiak Sciences Inc 114,7964.4M $
41ZENAS BIOPHARMA INC 214,3344.2M $
42Relay Therapeutics Inc 408,4364.1M $
43SAVARA INC 739,1644M $
44Corvus Pharmaceuticals Inc 247,9613.6M $
45Ovid therapeutics Inc 1,622,8283.6M $
46Disc Medicine Inc 53,5383.4M $
47Upstream Bio Inc 358,0003.2M $
48Palisade Bio Inc 1,733,4713M $
49DYNE THERAPEUTICS INC 160,5942.9M $
50Climb Bio Inc 419,2472.9M $
51SolarEdge Technologies Inc 52,8362.7M $
52Amgen Inc 7,5002.6M $
53CYTOKINETICS INC 39,8172.6M $
54STRUCTURE THERAPEUTICS INC 50,8002.4M $
55Kura Oncology Inc 295,5222.4M $
56Generate Biomedicines Inc 185,0002.3M $
57iShares Bitcoin Trust ETF 59,5052.3M $
58Contineum Therapeutics Inc 173,4752.3M $
59Tenax Therapeutics Inc 136,0152.2M $
60Prelude Therapeutics Inc 558,3391.9M $
61ASCENDIS PHARMA A/S 8,0001.8M $
62VERASTEM INC 343,6781.8M $
63Voyager Therapeutics Inc 469,7611.8M $
64Shattuck Labs Inc 280,7861.8M $
65Evommune Inc 78,2341.8M $
66BioAge Labs Inc 86,5181.5M $
67Organogenesis Holdings Inc 550,0001.3M $
68CURIS INC 1,994,9371.1M $
69Bristol-Myers Squibb Co 17,5001.1M $
70CYTOMX THERAPEUTICS INC 220,0001M $
71Nice Ltd 5,611618.7K $
72WEREWOLF THERAPEUTICS INC 626,810521.9K $
73SKYE BIOSCIENCE INC 678,928417.3K $
74Precision BioSciences Inc 40,000220K $
75APREA THERAPEUTICS INC 270,000206K $
76Foghorn Therapeutics Inc 12,22458.4K $

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Sector breakdown

  • Health care 18.5 %
  • Technology 1.9 %
  • Consumer discretionary 1.5 %
  • Unattributed 78.2 %

Titelia assigns each company to a sector, one by one. The unassigned share stays visible, under "Unattributed".

Currency breakdown

  • USD 100.0 %

Each line is counted in its quoted currency, as the fund declares it.

Country breakdown

  • United States 86.5 %
  • Israel 7.7 %
  • France 2.9 %
  • United Kingdom 1.5 %
  • Denmark 1.4 %

Shares are computed on the fund's equities only.

RankCountryLinesValueShare
1United States70390.7M $86.53 %
2Israel234.9M $7.72 %
3France113M $2.88 %
4United Kingdom16.7M $1.49 %
5Denmark26.3M $1.39 %
Cite this page

Titelia. "Holdings of SPHERA FUNDS MANAGEMENT LTD.". https://titelia.com/en/funds/US13F1496201