| 1 | Edgewise Therapeutics Inc | 15,518,492 | 488.8M $ | |
| 2 | Enliven Therapeutics Inc | 7,959,538 | 312M $ | |
| 3 | Eli Lilly & Co | 236,800 | 217.8M $ | |
| 4 | Boston Scientific Corp | 2,382,100 | 149.5M $ | |
| 5 | Sionna Therapeutics Inc | 3,530,702 | 141.5M $ | |
| 6 | MBX Biosciences Inc | 3,637,887 | 108.6M $ | |
| 7 | Corvus Pharmaceuticals Inc | 7,165,006 | 104.8M $ | |
| 8 | Argenx SE | 136,900 | 100M $ | |
| 9 | Edwards Lifesciences Corp | 1,230,600 | 98.5M $ | |
| 10 | Intuitive Surgical Inc | 208,700 | 96.2M $ | |
| 11 | Compass Therapeutics Inc | 15,219,994 | 80.5M $ | |
| 12 | Merck & Co Inc | 663,400 | 79.8M $ | |
| 13 | Structure Therapeutics Inc | 1,475,403 | 71.1M $ | |
| 14 | ArriVent Biopharma Inc | 3,027,328 | 69.8M $ | |
| 15 | Disc Medicine Inc | 1,067,550 | 68.3M $ | |
| 16 | ARS Pharmaceuticals Inc | 8,288,510 | 66.6M $ | |
| 17 | CG oncology Inc | 948,267 | 64.2M $ | |
| 18 | Stryker Corp | 182,500 | 60M $ | |
| 19 | Bristol-Myers Squibb Co | 925,000 | 56.1M $ | |
| 20 | Mineralys Therapeutics Inc | 2,052,900 | 55.6M $ | |
| 21 | Praxis Precision Medicines Inc | 172,500 | 55.6M $ | |
| 22 | Pfizer Inc | 1,946,500 | 54.7M $ | |
| 23 | Dyne Therapeutics Inc | 2,917,884 | 52.9M $ | |
| 24 | Natera Inc | 262,000 | 52.4M $ | |
| 25 | Abivax SA | 465,700 | 51.9M $ | |
| 26 | Upstream Bio Inc | 5,693,589 | 51.2M $ | |
| 27 | Danaher Corp | 265,800 | 50.4M $ | |
| 28 | Caris Life Sciences Inc | 2,806,811 | 50.2M $ | |
| 29 | Ascendis Pharma A/S | 181,977 | 41.6M $ | |
| 30 | Shattuck Labs Inc | 6,306,127 | 40.5M $ | |
| 31 | Guardant Health Inc | 435,200 | 40.2M $ | |
| 32 | Alnylam Pharmaceuticals Inc | 119,000 | 39.4M $ | |
| 33 | Prelude Therapeutics Inc | 10,909,256 | 37.3M $ | |
| 34 | Crinetics Pharmaceuticals Inc | 999,000 | 36.3M $ | |
| 35 | Axsome Therapeutics Inc | 213,921 | 36.2M $ | |
| 36 | ORIC Pharmaceuticals Inc | 2,693,929 | 34.1M $ | |
| 37 | Elevance Health Inc | 114,700 | 33.6M $ | |
| 38 | Relmada Therapeutics Inc | 4,715,864 | 32.8M $ | |
| 39 | Forte Biosciences Inc | 1,196,955 | 31M $ | |
| 40 | Trevi Therapeutics Inc | 2,454,400 | 29.3M $ | |
| 41 | Esperion Therapeutics Inc | 10,570,300 | 29M $ | |
| 42 | NeuroPace Inc | 2,096,527 | 27.6M $ | |
| 43 | Rhythm Pharmaceuticals Inc | 314,100 | 27.3M $ | |
| 44 | Thermo Fisher Scientific Inc | 46,500 | 22.9M $ | |
| 45 | Syndax Pharmaceuticals Inc | 962,300 | 22.5M $ | |
| 46 | BrightSpring Health Services Inc | 497,800 | 21.2M $ | |
| 47 | Lexeo Therapeutics Inc | 3,602,450 | 20.7M $ | |
| 48 | Sutro Biopharma Inc | 801,144 | 20M $ | |
| 49 | Nektar Therapeutics | 275,000 | 19.8M $ | |
| 50 | Krystal Biotech Inc | 69,100 | 17.8M $ | |
| 51 | Palvella Therapeutics Inc | 134,600 | 16.8M $ | |
| 52 | Corbus Pharmaceuticals Holdings Inc | 1,737,287 | 16.3M $ | |
| 53 | Vera Therapeutics Inc | 369,596 | 14.9M $ | |
| 54 | Q32 Bio Inc | 2,252,987 | 14.5M $ | |
| 55 | Aadi Bioscience Inc | 4,166,000 | 14.4M $ | |
| 56 | Amgen Inc | 39,900 | 14M $ | |
| 57 | Alignment Healthcare Inc | 791,000 | 13.9M $ | |
| 58 | EyePoint Inc | 1,069,147 | 13.8M $ | |
| 59 | Janux Therapeutics Inc | 983,600 | 13.7M $ | |
| 60 | BioCryst Pharmaceuticals Inc | 1,425,200 | 13.6M $ | |
| 61 | Bicara Therapeutics Inc | 667,300 | 13.3M $ | |
| 62 | BioAge Labs Inc | 711,811 | 12.4M $ | |
| 63 | Cogent Biosciences Inc | 322,100 | 12.4M $ | |
| 64 | Alumis Inc | 548,163 | 12.1M $ | |
| 65 | Regeneron Pharmaceuticals, Inc. | 14,700 | 11.4M $ | |
| 66 | Carlsmed Inc | 1,252,600 | 11.3M $ | |
| 67 | Biogen Inc | 61,600 | 11.3M $ | |
| 68 | Keros Therapeutics Inc | 759,155 | 8.4M $ | |
| 69 | Gilead Sciences Inc | 59,600 | 8.3M $ | |
| 70 | Heron Therapeutics Inc | 9,816,940 | 7.9M $ | |
| 71 | AVALO THERAPEUTICS INC | 475,165 | 7.1M $ | |
| 72 | Tectonic Therapeutic Inc | 226,600 | 7M $ | |
| 73 | Adicet Bio Inc | 1,027,944 | 7M $ | |
| 74 | Compass Pathways plc | 1,150,646 | 6.4M $ | |
| 75 | ALX Oncology Holdings Inc | 2,866,256 | 5.7M $ | |
| 76 | Artivion Inc | 151,000 | 5.5M $ | |
| 77 | InspireMD, Inc. | 3,133,405 | 5.1M $ | |
| 78 | Revolution Medicines Inc | 52,000 | 5.1M $ | |
| 79 | Protagonist Therapeutics Inc | 42,100 | 4.4M $ | |
| 80 | Palisade Bio Inc | 2,333,000 | 4.1M $ | |
| 81 | Alto Neuroscience Inc | 167,500 | 3.8M $ | |
| 82 | Savara Inc | 635,000 | 3.5M $ | |
| 83 | Cullinan Therapeutics Inc | 243,006 | 3.5M $ | |
| 84 | PTC Therapeutics Inc | 49,100 | 3.3M $ | |
| 85 | LifeStance Health Group Inc | 500,000 | 3.2M $ | |
| 86 | JADE BIOSCIENCES INC | 185,011 | 2.6M $ | |
| 87 | C4 Therapeutics Inc | 856,353 | 2.3M $ | |
| 88 | Avita Medical Inc | 544,895 | 2M $ | |
| 89 | KalVista Pharmaceuticals Inc | 94,400 | 1.9M $ | |
| 90 | IMAGENEBIO INC | 378,556 | 1.9M $ | |
| 91 | VISTAGEN THERAPEUTICS INC | 3,060,000 | 1.7M $ | |
| 92 | AtaiBeckley Inc | 347,000 | 1.2M $ | |
| 93 | TRAWS PHARMA INC | 605,531 | 1.1M $ | |